CDH1 promoter methylation in patients with cervical carcinoma: a systematic meta-analysis with trial sequential analysis

被引：11

作者：

Liu, Guanyuan ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Gynaecol & Obstet, 8 Workers Stadium South Rd, Beijing 100020, Peoples R China

来源：

FUTURE ONCOLOGY | 2018年 / 14卷 / 01期

关键词：

CDH1; cervical cancer; CIN lesions; histology; promoter methylation; INVASION-SUPPRESSOR GENE; SQUAMOUS-CELL CARCINOMA; E-CADHERIN; DNA-METHYLATION; BREAST-CANCER; EXPRESSION; HYPERMETHYLATION; RELEVANCE; SERUM; LINES;

D O I：

10.2217/fon-2017-0267

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: This study was performed to evaluate the correlation between CDH1 promoter methylation and cervical cancer. Methods: Trial sequential analysis was conducted to evaluate the required information size. Results: A total of 15 studies with 950 cervical cancers and 829 controls were identified. CDH1 promoter methylation was higher in cervical cancer than in cervical intraepithelial neoplasia lesions and normal cervical tissues. Subgroup analysis of ethnicity showed that CDH1 promoter methylation correlated with cervical cancer in Caucasians, but not in Asians. CDH1 promoter methylation was higher in cervical cancer cytology samples than in normal cytology samples. It was higher in squamous cell carcinoma than adenocarcinoma, but was not correlated with tumor stage, grade and overall survival. Conclusion: CDH1 promoter methylation may be correlated with cervical cancer carcinogenesis, especially for Caucasians. It was associated with histological subtypes. Trial sequential analysis showed that more studies are needed.

引用

页码：51 / 63

页数：13

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