Antigenemia at 10 years after diethylcarbamazine treatment of asymptomatic microfilaraemic individuals: marginal conversion to infection-free state

被引：6
作者：
Beuria, MK [1 ]
Bal, MS [1 ]
Mandal, NN [1 ]
Das, MK [1 ]
机构：
[1] Reg Med Res Ctr, ICMR, Div Immunol, Bhubaneswar 751023, Orissa, India
来源：
PARASITE IMMUNOLOGY | 2002年 / 24卷 / 02期
关键词：
filariasis; Wuchereria bancrofti; antigenemia; chemotherapy; Og4C3;
D O I：
10.1046/j.0141-9838.2001.00439.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A group of asymptomatic microfilaraemic individuals (n = 44, 29 males, 15 females) living in a Wuchereria bancrofti endemic region of Orissa, India, was treated with a standard regimen of diethylcarbamazine (12 days, 6 mg/kg) in 1990. The incidence of microfilaraemia and antigenemia (Og4C3) was determined after a gap of 10 years in 2000. Nineteen individuals reacquired microfilariae (43.2%, 11 males, eight females), five males developed hydrocele, two females became acute filarial patients and 18 subjects (13 males, five females) were asymptomatic amicrofilaraemics. Filarial antigen was detected in 36 individuals (81.2%, 27 male, ninefemale) comprising microfilaraemics, amicrofilaraemics and diseased. Only eight individuals (18.2%, two males, six females) remained antigen free.
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页码：109 / 111
页数：3
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