Y chromosome azoospermia factor region microdeletions and recurrent pregnancy loss

被引：45
|
作者：
Karaer, Abdullah [1 ]
Karaer, Kadri [3 ]
Ozaksit, Gulnur [1 ]
Ceylaner, Serdar [2 ]
Percin, E. Ferda [3 ]
机构：
[1] Dr Zekai Tahir Burak Woman Hlth Educ & Res Hosp, Dept Obstet & Gynecol, Ankara, Turkey
[2] Dr Zekai Tahir Burak Woman Hlth Educ & Res Hosp, Dept Med Genet, Ankara, Turkey
[3] Gazi Univ, Sch Med, Dept Med Genet, Ankara, Turkey
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2008年 / 199卷 / 06期
关键词：
AZF regions; recurrent pregnancy loss; Y chromosome microdeletion;
D O I：
10.1016/j.ajog.2008.06.013
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: This study was undertaken to determine the prevalence of Y-chromosome microdeletions in couples with recurrent pregnancy loss (RPL) as compared with fertile couples. STUDY DESIGN: Forty-three men from couples with recurrent pregnancy loss, and 43 men from couples with a live birth and no history of miscarriages were recruited from Zekai Tahir Burak Woman Health, Education and Research Hospital. The DNA was tested for the presence of 4 sequence tagged sites (STSs) spanning 4 AZF regions: DYS220 (AZFb), DYS235, DYS236, and DYS237 (AZFd). RESULTS: Seven (7) of the 43 men (16%) from couples with recurrent pregnancy loss had microdeletions in 1 or more of the 4 segments studied, whereas none of the fertile men had any microdeletions (P < .05). Their microdeletions were all found specifically at locus DYS 220 (AZFb). CONCLUSION: The prevalence of the Y chromosome microdeletion in AZF region was much higher in men from couples with recurrent pregnancy loss than men in fertile couples. This study showed that Y chromosome microdeletion in AZF region may be a possible etiologic factor of recurrent pregnancy loss.
引用
收藏
页码：662.e1 / 662.e5
页数：5
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