miRNAs in Bone Development

被引：17
作者：
Papaioannou, Garyfallia [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
CURRENT GENOMICS | 2015年 / 16卷 / 06期
关键词：
Bone; Cartilage; Chondrocytes; Mesenchymal stem cells; mi-RNAs; Osteoblasts; Skeletal development; HYPERTROPHIC CHONDROCYTE DIFFERENTIATION; MESENCHYMAL STEM-CELLS; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; PROLIFERATION; GROWTH; EXPRESSION; SOX9; SUPPRESSES; REGULATOR;
D O I：
10.2174/1389202916666150817202425
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Skeletal development is a multistage process during which mesenchymal progenitor cells undergo proliferation and differentiation and subsequently give rise to bone and cartilage forming cells. Each step is regulated by various transcription factors and signaling molecules. microRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Several in vivo and in vitro studies have shown that miRNAs play significant roles in skeletal development. Identifying their functions may give insights into the treatment of developmental disorders of the skeleton. This review summarizes miRNAs that have been shown to participate in various stages of skeletal development by targeting crucial factors.
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收藏
页码：427 / 434
页数：8
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