Calcium Channels and Prostate Cancer

被引：2

作者：

Shapovalov, George ^{[1
]}

Skryma, Roman ^{[1
]}

Prevarskaya, Natalia ^{[1
]}

机构：

[1] USTL, INSERM, U1003, Equipe Labellisee Ligue Natl Canc, F-59655 Villeneuve Dascq, France

来源：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY | 2013年 / 8卷 / 01期

关键词：

Apoptosis; calcium channels; cell fate; patent; proliferation; prostate cancer; STORE-OPERATED CHANNELS; NF-KAPPA-B; PANNEXIN; CHANNELS; ENDOPLASMIC-RETICULUM; CA2+ RELEASE; TRP CHANNELS; APOPTOTIC RESISTANCE; CELL-PROLIFERATION; KINASE-II; PROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Calcium channels significantly contribute to many cellular processes, including such critical ones as proliferation, differentiation, and apoptosis. In prostate cancer, the influence of calcium channels has been known for over 30 years, with the first observations that calcium channel blockers affect the progression of cancer towards more aggressive phase. Later research identified additional classes of channel proteins having an important regulatory role and affecting malignant transformation. This review discusses the accumulated scientific knowledge focused on calcium channel involvement in regulation of cell fate in prostate tissues as well as recent developments in patents targeted at prostate cancer treatments and involving calcium channel modulators.

引用

页码：18 / 26

页数：9

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