Enhancing Solubility and Bioavailability of Artemether and Lumefantrine through a Self-nano Emulsifying Drug Delivery System

In the present study artemether and lumefantrine self-nano emulsifying drug delivery system formulations were prepared using combination of these drugs with Capmul medical countermeasure, oleic acid and Tween 80. The particle size and zeta potential of these formulations was found to be 15.2 nm and -22.8 mV. The solubility and in vitro dissolution performance of both drugs in self-nano emulsifying drug delivery system formulations was improved significantly as compared to pure drugs and marketed product and the in vivo studies confirmed it. In vivo studies in rats revealed that there was an increase in bioavailability of self-nano emulsifying drug delivery system formulations compared to pure drugs with the area under the curve of artemether from formulation was 598.89 +/- 114.33 in comparison to that of pure artemether 190.82 +/- 36.57 and the area under the curve for lumefantrine from the formulations was 190.82 +/- 36.57 in comparison to that of the pure lumefantrine 68.71 +/- 18.63. The C-max was enhanced for artemether from 13.11 +/- 2.22 to 110.31 +/- 40.88 and for lumefantrine from 2.39 +/- 1.61 to 18.22 +/- 2.32.