Predictors of mortality in Middle East respiratory syndrome (MERS)

被引：153

作者：

Hong, Ki-Ho ^{[1
]}

Choi, Jae-Phil ^{[2
]}

Hong, Seon-Hui ^{[3
]}

Lee, Jeewon ^{[3
]}

Kwon, Ji-Soo ^{[3
,4
]}

Kim, Sun-Mi ^{[4
]}

Park, Se Yoon ^{[4
]}

Rhee, Ji-Young ^{[5
]}

Kim, Baek-Nam ^{[6
]}

Choi, Hee Jung ^{[7
]}

Shin, Eui-Cheol ^{[3
,8
]}

Pai, Hyunjoo ^{[9
]}

Park, Su-Hyung ^{[3
,8
]}

Kim, Sung-Han ^{[4
]}

机构：

[1] Seoul Med Ctr, Dept Lab Med, Seoul, South Korea

[2] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea

[3] Korea Adv Inst Sci & Technol, Biomed Sci & Engn Interdisciplinary Program, Daejeon, South Korea

[4] Univ Ulsan, Dept Infect Dis, Asan Med Ctr, Coll Med, 388-1 Pungnap Dong, Seoul 05505, South Korea

[5] Dankook Univ Hosp, Div Infect Dis, Dept Internal Med, Cheonan, South Korea

[6] Inje Univ, Dept Internal Med, Sanggye Paik Hosp, Seoul, South Korea

[7] Ewha Womans Univ Hosp, Dept Internal Med, Seoul, South Korea

[8] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea

[9] Han Yang Univ Hosp, Dept Internal Med, Seoul, South Korea

来源：

THORAX | 2018年 / 73卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

viral infection; respiratory infection; infection control;

D O I：

10.1136/thoraxjnl-2016-209313

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.

引用

页码：286 / 289

页数：4

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