Effect of paroxetine on marble-burying behavior in mice

被引:16
|
作者
Shinomiya, K
Fujii, Y
Sugimoto, Y
Azuma, N
Tokunaga, S
Kitazumi, K
Kamei, C
机构
[1] Okayama Univ, Grad Sch Med & Dent Pharmaceut Sci, Dept Med Pharmacol, Okayama 7008530, Japan
[2] GlaxoSmithKline KK, Preclin Dev Dept, Dev & Med Affairs Div, Tokyo, Japan
来源
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2005年 / 27卷 / 10期
关键词
clomipramine; fluvoxamine; marble-burying behavior; mice; paroxetine;
D O I
10.1358/mf.2005.27.10.948883
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI). on marble-burying behavior in mice in comparison with those of fluvoamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of,10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine. a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand. all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirnied that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/ anticompulsive activity in hunan beings. (c) 2005 Prous Science. All rights reserved.
引用
收藏
页码:685 / 687
页数:3
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