Alpha-fetoprotein: A controversial prognostic biomarker for small hepatocellular carcinoma

被引：16

作者：

Asrih, Mohamed ^{[1
]}

Lenglet, Sebastien ^{[1
]}

Mach, Francois ^{[1
]}

Montecucco, Fabrizio ^{[1
,2
]}

机构：

[1] Fdn Med Res, Univ Hosp Geneva, Dept Med, Div Cardiol, CH-1211 Geneva, Switzerland

[2] Univ Genoa, Dept Internal Med, Clin Internal Med 1, I-16126 Genoa, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Hepatocellular carcinoma; Alpha-fetoprotein; Prognosis; Cirrhosis; Biomarker; HEPATITIS-C; SURVEILLANCE;

D O I：

10.3748/wjg.v19.i3.328

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The assessment of the prognosis in patients with early hepatocellular carcinoma represents a hot-topic issue that requires further improvements and clarifications. The life expectancy of the patients has been shown to depend on several clinical and histological parameters (such as patient's general conditions, macroscopic tumor morphology and histopathology). Recently, the prognostic role of some biomarkers [i.e., alpha-fetoprotein (AFP)] has been also investigated with controversial findings mainly on the assessment of patient survival. The study by Giannini et al failed to show a prognostic value of AFP on survival of patients with well-compensated cirrhosis and small hepatocellular carcinoma. Since the study presents some limitations, a larger clinical trial is needed to clarify the potential prognostic role of serum AFP levels in these patients. (C) 2013 Baishideng. All rights reserved.

引用

页码：328 / 330

页数：3

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