The Requirement for Cyclin D Function in Tumor Maintenance

被引：284

作者：

Choi, Yoon Jong ^{[1
,8
]}

Li, Xiaoyu ^{[3
,9
]}

Hydbring, Per ^{[1
,8
]}

Sanda, Takaomi ^{[2
,7
,10
]}

Stefano, Joanna ^{[1
]}

Christie, Amanda L. ^{[4
]}

Signoretti, Sabina ^{[5
,6
]}

Look, A. Thomas ^{[2
,7
,10
]}

Kung, Andrew L. ^{[4
,10
]}

von Boehmer, Harald ^{[3
,9
]}

Sicinski, Piotr ^{[1
,8
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA

[3] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02215 USA

[4] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02215 USA

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[6] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[7] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[9] Harvard Univ, Sch Med, Dept Microbiol & Immunol, Boston, MA 02115 USA

[10] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

CANCER CELL | 2012年 / 22卷 / 04期

基金：

日本学术振兴会;

关键词：

TRANSGENIC MICE; CELLULAR SENESCENCE; OXIDATIVE STRESS; BREAST-CANCER; IN-VIVO; TUMORIGENESIS; CELLS; GENE; ONCOGENESIS; INHIBITION;

D O I：

10.1016/j.ccr.2012.09.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence, without compromising the animals' health. Ablation of cyclin D3 in mice bearing Notch 1-driven T cell acute lymphoblastic leukemias (T-ALL) triggered tumor cell apoptosis. Such selective killing of leukemic cells can also be achieved by inhibiting cyclin D associated kinase activity in mouse and human T-ALL models. Inhibition of cyclin D-kinase activity represents a highly-selective anticancer strategy that specifically targets cancer cells without significantly affecting normal tissues.

引用

页码：438 / 451

页数：14

共 51 条

[1] A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells [J].

Anders, Lars ;

Ke, Nan ;

Hydbring, Per ;

Choi, Yoon J. ;

Widlund, Hans R. ;

Chick, Joel M. ;

Zhai, Huili ;

Vidal, Marc ;

Gygi, Stephen P. ;

Braun, Pascal ;

Sicinski, Piotr .

CANCER CELL, 2011, 20 (05) :620-634

[2] The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

[3] CYCLIN D1 TRANSGENE IMPEDES LYMPHOCYTE MATURATION AND COLLABORATES IN LYMPHOMAGENESIS WITH THE MYC GENE [J].

BODRUG, SE ;

WARNER, BJ ;

BATH, ML ;

LINDEMAN, GJ ;

HARRIS, AW ;

ADAMS, JM .

EMBO JOURNAL, 1994, 13 (09) :2124-2130

[4] Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E [J].

Bowe D.B. ;

Kenney N.J. ;

Adereth Y. ;

Maroulakou I.G. .

Oncogene, 2002, 21 (2) :291-298

[5] Cyclin D2 and P27 are tissue-specific regulators of tumorigenesis in inhibin α knockout mice [J].

Burns, KH ;

Agno, JE ;

Sicinski, P ;

Matzuk, MM .

MOLECULAR ENDOCRINOLOGY, 2003, 17 (10) :2053-2069

[6]

Chaganti RSK, 2000, CANCER RES, V60, P1475

[7] Division and apoptosis of E2f-deficient retinal progenitors [J].

Chen, Danian ;

Pacal, Marek ;

Wenzel, Pamela ;

Knoepfler, Paul S. ;

Leone, Gustavo ;

Bremner, Rod .

NATURE, 2009, 462 (7275) :925-U120

[8] Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1 [J].

Chiang, Mark Y. ;

Xu, Mina L. ;

Histen, Gavin ;

Shestova, Olga ;

Roy, Monideepa ;

Nam, Yunsun ;

Blacklow, Stephen C. ;

Sacks, David B. ;

Pear, Warren S. ;

Aster, Jon C. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (16) :6261-6271

[9] Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence [J].

Chicas, Agustin ;

Wang, Xiaowo ;

Zhang, Chaolin ;

McCurrach, Mile ;

Zhao, Zhen ;

Mert, Ozlem ;

Dickins, Ross A. ;

Narita, Masashi ;

Zhang, Michael ;

Lowe, Scott W. .

CANCER CELL, 2010, 17 (04) :376-387

[10] E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells [J].

Chong, Jean-Leon ;

Wenzel, Pamela L. ;

Saenz-Robles, M. Teresa ;

Nair, Vivek ;

Ferrey, Antoney ;

Hagan, John P. ;

Gomez, Yorman M. ;

Sharma, Nidhi ;

Chen, Hui-Zi ;

Ouseph, Madhu ;

Wang, Shu-Huei ;

Trikha, Prashant ;

Culp, Brian ;

Mezache, Louise ;

Winton, Douglas J. ;

Sansom, Owen J. ;

Chen, Danian ;

Bremner, Rod ;

Cantalupo, Paul G. ;

Robinson, Michael L. ;

Pipas, James M. ;

Leone, Gustavo .

NATURE, 2009, 462 (7275) :930-934

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