Zonisamide has beneficial effects on Parkinson's disease patients

被引：116

作者：

Murata, M ^{[1
]}

Horiuchi, E ^{[1
]}

Kanazawa, I ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

NEUROSCIENCE RESEARCH | 2001年 / 41卷 / 04期

关键词：

zonisamide; Parkinson's disease; levodopa; anticonvulsant;

D O I：

10.1016/S0168-0102(01)00298-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Zonisamide (ZNS) is a generally well tolerated anticonvulsant that has beneficial effects on Parkinson's disease (PD). ZNS (300 mg/day) given to a patient with PD who incidentally had convulsive attacks, ameliorated the attacks and, surprisingly, his parkinsonian symptoms. We, therefore, carried out an open trial of ZNS on nine patients with PD. Patients were given 50-200 mg/day ZNS in addition to their anti-PD drugs. Seven clearly showed lessening of symptoms, especially wearing-off. We speculate that long lasting activation of dopamine synthesis by ZNS ameliorates parkinsonian symptoms, in particular wearing-off. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：397 / 399

页数：3

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