Formulation, characterization, in vitro and in vivo evaluation of castor oil based self-nano emulsifying levosulpiride delivery systems

被引：19

作者：

Poorani, G. ^{[1
]}

Uppuluri, Spandana ^{[2
]}

Uppuluri, Kiran Babu ^{[1
]}

机构：

[1] SASTRA Univ, Sch Chem & Biotechnol, Bioprospecting Lab, Thanjavur, India

[2] Nirmala Coll Pharm, Dept Pharmaceut Chem, Mangalagiri, India

来源：

JOURNAL OF MICROENCAPSULATION | 2016年 / 33卷 / 06期

关键词：

Levosulpiride; pseudo-ternary diagram; castor oil; optimisation; SNEDDS; dissolution modelling; bioavailability; ORAL DELIVERY; EDIBLE OILS; DRUG; BIOAVAILABILITY; DESIGN; SNEDDS; CARRIERS; OPTIMIZATION; DISSOLUTION; RELEASE;

D O I：

10.1080/02652048.2016.1223199

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Context: Levosulpiride (LSP) is a hydrophobic benzamide derivative used in the treatment of schizophrenia. SNEDDS were extensively practiced for systemic delivery of poorly aqueous soluble drugs to achieve maximum bioavailability.Objective: The present study was focussed on the formulation, optimisation and evaluation of LSP SNEDDS using castor oil, for enhancement of drug absorption and bioavailability.Materials and methods: Pseudo-ternary phase diagram was plotted to identify the range of SNEDDS components. Twenty formulations were designed, prepared and characterised by its particle size, zeta potential, viscosity, and stability. In vitro dissolution data modelling was performed. Microscopy, FTIR and in vivo bioavailability studies were conducted for optimum formulation.Results, discussion and conclusion: F18 containing castor oil, 0.9mL; PEG 600, 1.36mL and Tween 80, 2.74mL was found to be optimum. The optimised formulation had shown uniform globule size, no interactions of LSP with SNEDDS components and higher pharmacokinetic parameters than that of commercial preparation.

引用

页码：535 / 543

页数：9