Facilitating pharmacometric workflow with the metrumrg package for R

被引：17

作者：

Bergsma, Timothy T. ^{[1
]}

Knebel, William ^{[1
]}

Fisher, Jeannine ^{[1
]}

Gillespie, William R. ^{[1
]}

Riggs, Matthew M. ^{[1
]}

Gibiansky, Leonid ^{[2
]}

Gastonguay, Marc R. ^{[1
]}

机构：

[1] Metrum Inst, Tariffville, CT USA

[2] QuantPharm LLC, N Potomac, MD USA

来源：

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE | 2013年 / 109卷 / 01期

关键词：

metrumrg; Pharmacometrics; NONMEM (R); R software; Workflow;

D O I：

10.1016/j.cmpb.2012.08.009

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

metrumrg is an R package that facilitates workflow for the discipline of pharmacometrics. Support is provided for data preparation, modeling, simulation, diagnostics, and reporting. Existing tools and techniques are emphasized where available; original solutions are provided for otherwise unmet needs. In particular, metrumrg implements an R interface for the NONMEM (R) modeling software, optionally run in a distributed computing environment. The paradigm allows start-to-finish analyses in a single scripting language. Emphasis on text-based formats promotes traceability of results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：77 / 85

页数：9

共 18 条

[1]

[Anonymous], 2008, R REG COMPL VAL ISS

[2]

[Anonymous], 2006, PDX MCPEM US GUID VE

[3] A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples [J].