Relevance of tumor-infiltrating lymphocytes in breast cancer

被引：186

作者：

Dushyanthen, Sathana ^{[1
]}

Beavis, Paul A. ^{[1
]}

Savas, Peter ^{[1
]}

Teo, Zhi Ling ^{[1
]}

Zhou, Chenhao ^{[1
]}

Mansour, Mariam ^{[1
]}

Darcy, Phillip K. ^{[1
,2
]}

Loi, Sherene ^{[1
,2
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Div Res & Canc Med, East Melbourne, Vic, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia

[3] Peter MacCallum Canc Ctr, Div Res & Canc Med, East Melbourne, Vic, Australia

来源：

BMC MEDICINE | 2015年 / 13卷

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Breast cancer; HER2; immunity; immunotherapy; NAC; neoadjuvant chemotherapy; TILs; TNBC; triple negative breast cancer; tumor-infiltrating lymphocytes; REGULATORY T-CELLS; PATHOLOGICAL COMPLETE RESPONSE; NEOADJUVANT CHEMOTHERAPY; SUPPRESSOR-CELLS; ANTITUMOR IMMUNITY; PREDICT RESPONSE; ANTICANCER CHEMOTHERAPY; ADOPTIVE IMMUNOTHERAPY; CHECKPOINT BLOCKADE; ESTABLISHED TUMORS;

D O I：

10.1186/s12916-015-0431-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

While breast cancer has not been considered a cancer amenable to immunotherapeutic approaches, recent studies have demonstrated evidence of significant immune cell infiltration via tumor-infiltrating lymphocytes in a subset of patient tumors. In this review we present the current evidence highlighting the clinical relevance and utility of tumor-infiltrating lymphocytes in breast cancer. Retrospective and prospective studies have shown that the presence of tumor-infiltrating lymphocytes is a prognostic marker for higher responses to neoadjuvant chemotherapy and better survival, particularly in triple negative and HER2-positive early breast cancer. Further work is required to determine the immune subsets important in this response and to discover ways of encouraging immune infiltrate in tumor-infiltrating lymphocytes-negative patients.

引用

页数：13

共 143 条

[1] Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199 [J].

Adams, Sylvia ;

Gray, Robert J. ;

Demaria, Sandra ;

Goldstein, Lori ;

Perez, Edith A. ;

Shulman, Lawrence N. ;

Martino, Silvana ;

Wang, Molin ;

Jones, Vicky E. ;

Saphner, Thomas J. ;

Wolff, Antonio C. ;

Wood, William C. ;

Davidson, Nancy E. ;

Sledge, George W. ;

Sparano, Joseph A. ;

Badve, Sunil S. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :2959-+

[2] Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma [J].

Ahmed, Nabil ;

Brawley, Vita S. ;

Hegde, Meenakshi ;

Robertson, Catherine ;

Ghazi, Alexia ;

Gerken, Claudia ;

Liu, Enli ;

Dakhova, Olga ;

Ashoori, Aidin ;

Corder, Amanda ;

Gray, Tara ;

Wu, Meng-Fen ;

Liu, Hao ;

Hicks, John ;

Rainusso, Nino ;

Dotti, Gianpietro ;

Mei, Zhuyong ;

Grilley, Bambi ;

Gee, Adrian ;

Rooney, Cliona M. ;

Brenner, Malcolm K. ;

Heslop, Helen E. ;

Wels, Winfried S. ;

Wang, Lisa L. ;

Anderson, Peter ;

Gottschalk, Stephen .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15) :1688-+

[3] Association between CD8+T-cell infiltration and breast cancer survival in 12 439 patients [J].

Ali, H. R. ;

Provenzano, E. ;

Dawson, S-J ;

Blows, F. M. ;

Liu, B. ;

Shah, M. ;

Earl, H. M. ;

Poole, C. J. ;

Hiller, L. ;

Dunn, J. A. ;

Bowden, S. J. ;

Twelves, C. ;

Bartlett, J. M. S. ;

Mahmoud, S. M. A. ;

Rakha, E. ;

Ellis, I. O. ;

Liu, S. ;

Gao, D. ;

Nielsen, T. O. ;

Pharoah, P. D. P. ;

Caldas, C. .

ANNALS OF ONCOLOGY, 2014, 25 (08) :1536-1543

[4] Dual roles for immune metagenes in breast cancer prognosis and therapy prediction [J].

Alistar, Angela ;

Chou, Jeff W. ;

Nagalla, Srikanth ;

Black, Michael A. ;

D'Agostino, Ralph, Jr. ;

Miller, Lance D. .

GENOME MEDICINE, 2014, 6

[5] Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer [J].

Alizadeh, Darya ;

Trad, Malika ;

Hanke, Neale T. ;

Larmonier, Claire B. ;

Janikashvili, Nona ;

Bonnotte, Bernard ;

Katsanis, Emmanuel ;

Larmonier, Nicolas .

CANCER RESEARCH, 2014, 74 (01) :104-118

[6] Molecular Pathways: Involvement of Immune Pathways in the Therapeutic Response and Outcome in Breast Cancer [J].

Andre, Fabrice ;

Dieci, Maria V. ;

Dubsky, Peter ;

Sotiriou, Christos ;

Curigliano, Giuseppe ;

Denkert, Carsten ;

Loi, Sherene .

CLINICAL CANCER RESEARCH, 2013, 19 (01) :28-33

[7] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[8] Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? [J].

Arnould, L ;

Gelly, M ;

Penault-Llorca, F ;

Benoit, L ;

Bonnetain, F ;

Migeon, C ;

Cabaret, V ;

Fermeaux, V ;

Bertheau, P ;

Garnier, J ;

Jeannin, JF ;

Coudert, B .

BRITISH JOURNAL OF CANCER, 2006, 94 (02) :259-267

[9] A low number of tumor-infiltrating FOXP3-positive cells during primary systemic chemotherapy correlates with favorable anti-tumor response in patients with breast cancer [J].

Aruga, Tomoyuki ;

Suzuki, Eiji ;

Saji, Shigehira ;

Horiguchi, Shin-Ichirou ;

Horiguchi, Kazumi ;

Sekine, Susumu ;

Kitagawa, Dai ;

Funata, Nobuaki ;

Toi, Masakazu ;

Sugihara, Kenichi ;

Kuroi, Katsumasa .

ONCOLOGY REPORTS, 2009, 22 (02) :273-278

[10] Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses [J].

Beavis, Paul A. ;

Milenkovski, Nicole ;

Henderson, Melissa A. ;

John, Liza B. ;

Allard, Bertrand ;

Loi, Sherene ;

Kershaw, Michael H. ;

Stagg, John ;

Darcy, Phillip K. .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (05) :506-517

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