Relevance of tumor-infiltrating lymphocytes in breast cancer

被引：186

作者：

Dushyanthen, Sathana ^{[1
]}

Beavis, Paul A. ^{[1
]}

Savas, Peter ^{[1
]}

Teo, Zhi Ling ^{[1
]}

Zhou, Chenhao ^{[1
]}

Mansour, Mariam ^{[1
]}

Darcy, Phillip K. ^{[1
,2
]}

Loi, Sherene ^{[1
,2
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Div Res & Canc Med, East Melbourne, Vic, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia

[3] Peter MacCallum Canc Ctr, Div Res & Canc Med, East Melbourne, Vic, Australia

来源：

BMC MEDICINE | 2015年 / 13卷

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Breast cancer; HER2; immunity; immunotherapy; NAC; neoadjuvant chemotherapy; TILs; TNBC; triple negative breast cancer; tumor-infiltrating lymphocytes; REGULATORY T-CELLS; PATHOLOGICAL COMPLETE RESPONSE; NEOADJUVANT CHEMOTHERAPY; SUPPRESSOR-CELLS; ANTITUMOR IMMUNITY; PREDICT RESPONSE; ANTICANCER CHEMOTHERAPY; ADOPTIVE IMMUNOTHERAPY; CHECKPOINT BLOCKADE; ESTABLISHED TUMORS;

D O I：

10.1186/s12916-015-0431-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

While breast cancer has not been considered a cancer amenable to immunotherapeutic approaches, recent studies have demonstrated evidence of significant immune cell infiltration via tumor-infiltrating lymphocytes in a subset of patient tumors. In this review we present the current evidence highlighting the clinical relevance and utility of tumor-infiltrating lymphocytes in breast cancer. Retrospective and prospective studies have shown that the presence of tumor-infiltrating lymphocytes is a prognostic marker for higher responses to neoadjuvant chemotherapy and better survival, particularly in triple negative and HER2-positive early breast cancer. Further work is required to determine the immune subsets important in this response and to discover ways of encouraging immune infiltrate in tumor-infiltrating lymphocytes-negative patients.

引用

页数：13

共 143 条

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