RAC1 as a Therapeutic Target in Malignant Melanoma

被引：47

作者：

Cannon, Alexa C. ^{[1
]}

Uribe-Alvarez, Cristina ^{[2
]}

Chernoff, Jonathan ^{[2
]}

机构：

[1] Drexel Univ, Coll Med, 245 N 15th St, Philadelphia, PA 19102 USA

[2] Fox Chase Canc Ctr, 333 Cottman Ave, Philadelphia, PA 19111 USA

来源：

TRENDS IN CANCER | 2020年 / 6卷 / 06期

关键词：

SMALL-MOLECULE INHIBITOR; BREAST-CANCER; RATIONAL DESIGN; SPLICE VARIANT; LUNG-CANCER; RHO-GTPASES; RAS; ACTIVATION; EXPRESSION; OVEREXPRESSION;

D O I：

10.1016/j.trecan.2020.02.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small GTPases of the RAS and RHO families are related signaling proteins that, when activated by growth factors or by mutation, drive oncogenic processes. While activating mutations in KRAS, NRAS, and HRAS genes have long been recognized and occur in many types of cancer, similar mutations in RHO family genes, such as RAC1 and RHOA, have only recently been detected as the result of extensive cancer genome-sequencing efforts and are linked to a restricted set of malignancies. In this review, we focus on the role of RAC1 signaling in malignant melanoma, emphasizing recent advances that describe how this oncoprotein alters melanocyte proliferation and motility and how these findings might lead to new therapeutics in RAC1-mutant tumors.

引用

页码：478 / 488

页数：11

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