Effects of sphingolipid metabolism disorders on endothelial cells

被引：22

作者：

Lai, Yali ^{[1
]}

Tian, Yue ^{[1
]}

You, Xintong ^{[1
]}

Du, Jiangnan ^{[1
]}

Huang, Jianmei ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Tradit Chinese Mat Med, Beijing, Peoples R China

来源：

LIPIDS IN HEALTH AND DISEASE | 2022年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Sphingolipid metabolism; Endothelial cells; Sphingosine-1-phosphate; Sphingosine kinase; Ceramide; Serine; Ceramide kinase; Sphingosine-1-phosphate lyase; Cardiovascular disease; SPHINGOSINE-1-PHOSPHATE RECEPTOR 2; SPHINGOSINE KINASE; VASCULAR-PERMEABILITY; OVER-EXPRESSION; PRECURSOR CELLS; CERAMIDE; ACTIVATION; 1-PHOSPHATE; ANGIOGENESIS; DYSFUNCTION;

D O I：

10.1186/s12944-022-01701-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related to sphingolipid metabolism, and normal sphingolipid metabolism is critical for maintaining endothelial cell homeostasis. Sphingolipid metabolites or key enzymes in abnormal situation, including sphingosine, ceramide (Cer), sphingosine-1-phosphate (S1P), serine, sphingosine kinase (SPHK), ceramide kinase (Cerk), sphingosine-1-phosphate lyase (S1PL) etc., may have a protective or damaging effect on the function of endothelial cells. This review summarizes the effects of sphingolipid metabolites and key enzymes disordering in sphingolipid metabolism on endothelial cells, offering some insights into further research on the pathogenesis of cardiovascular diseases and corresponding therapeutic targets.

引用

页数：12

共 75 条

[1] High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function [J].

Argraves, Kelley M. ;

Gazzolo, Patrick J. ;

Groh, Eric M. ;

Wilkerson, Brent A. ;

Matsuura, Bryan S. ;

Twal, Waleed O. ;

Hammad, Samar M. ;

Argraves, W. Scott .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (36) :25074-25081

[2] Vascular sphingolipids in physiological and pathological adaptation [J].

Bao, Jun-Xiang ;

Su, Yu-Ting ;

Cheng, Yao-Ping ;

Zhang, Hai-Jun ;

Xie, Xiao-Ping ;

Chang, Yao-Ming .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2016, 21 :1168-1186

[3] Over-Expression of Sphingosine Kinase-1 Enhances a Progenitor Phenotype in Human Endothelial Cells [J].

Barrett, Jeffrey M. ;

Parham, Kate A. ;

Pippal, Jyotsna B. ;

Cockshell, Michaelia P. ;

Moretti, Paul A. B. ;

Brice, Sarah L. ;

Pitson, Stuart M. ;

Bonder, Claudine S. .

MICROCIRCULATION, 2011, 18 (07) :583-597

[4] Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide [J].

Cantalupo, Anna ;

Sasset, Linda ;

Gargiulo, Antonella ;

Rubinelli, Luisa ;

Del Gaudio, Ilaria ;

Benvenuto, Domenico ;

Wadsack, Christian ;

Jiang, Xiang-Chen ;

Bucci, Maria Rosaria ;

Di Lorenzo, Annarita .

HYPERTENSION, 2020, 75 (05) :1279-1288

[5] Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction [J].

Chen, Shuhua ;

Yang, Jie ;

Xiang, Hong ;

Chen, Wei ;

Zhong, Hua ;

Yang, Guoping ;

Fang, Ting ;

Deng, Hao ;

Yuan, Hong ;

Chen, Alex F. ;

Lu, Hongwei .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 35 (04) :1103-1108

[6] Mobilized endothelial progenitor cells by granulocyte-macrophage colony-stimulating factor accelerate reendothelialization and reduce vascular inflammation after intravascular radiation [J].

Cho, HJ ;

Kim, HS ;

Lee, MM ;

Kim, DH ;

Yang, HJ ;

Hur, J ;

Hwang, KK ;

Oh, S ;

Choi, YJ ;

Chae, IH ;

Oh, BH ;

Choi, YS ;

Walsh, K ;

Park, YB .

CIRCULATION, 2003, 108 (23) :2918-2925

[7] Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M [J].

Christoffersen, Christina ;

Obinata, Hideru ;

Kumaraswamy, Sunil B. ;

Galvani, Sylvain ;

Ahnstrom, Josefin ;

Sevvana, Madhumati ;

Egerer-Sieber, Claudia ;

Muller, Yves A. ;

Hla, Timothy ;

Nielsen, Lars B. ;

Dahlback, Bjorn .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) :9613-9618

[8] Ceramide and Regulation of Vascular Tone [J].

Cogolludo, Angel ;

Villamor, Eduardo ;

Perez-Vizcaino, Francisco ;

Moreno, Laura .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (02)

[9] Glycosphingolipids promote pro-atherogenic pathways in the pathogenesis of hyperglycemia-induced accelerated atherosclerosis [J].

Dang, Vi T. ;

Zhong, Lexy H. ;

Huang, Aric ;

Deng, Arlinda ;

Werstuck, Geoff H. .

METABOLOMICS, 2018, 14 (07)

[10] Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms [J].

Dennhardt, Sophie ;

Finke, Karl R. ;

Huwiler, Andrea ;

Coldewey, Sina M. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2019, 1865 (04) :774-781

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