Effects of sphingolipid metabolism disorders on endothelial cells

被引：17
|
作者：
Lai, Yali [1 ]
Tian, Yue [1 ]
You, Xintong [1 ]
Du, Jiangnan [1 ]
Huang, Jianmei [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Tradit Chinese Mat Med, Beijing, Peoples R China
来源：
LIPIDS IN HEALTH AND DISEASE | 2022年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Sphingolipid metabolism; Endothelial cells; Sphingosine-1-phosphate; Sphingosine kinase; Ceramide; Serine; Ceramide kinase; Sphingosine-1-phosphate lyase; Cardiovascular disease; SPHINGOSINE-1-PHOSPHATE RECEPTOR 2; SPHINGOSINE KINASE; VASCULAR-PERMEABILITY; OVER-EXPRESSION; PRECURSOR CELLS; CERAMIDE; ACTIVATION; 1-PHOSPHATE; ANGIOGENESIS; DYSFUNCTION;
D O I：
10.1186/s12944-022-01701-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related to sphingolipid metabolism, and normal sphingolipid metabolism is critical for maintaining endothelial cell homeostasis. Sphingolipid metabolites or key enzymes in abnormal situation, including sphingosine, ceramide (Cer), sphingosine-1-phosphate (S1P), serine, sphingosine kinase (SPHK), ceramide kinase (Cerk), sphingosine-1-phosphate lyase (S1PL) etc., may have a protective or damaging effect on the function of endothelial cells. This review summarizes the effects of sphingolipid metabolites and key enzymes disordering in sphingolipid metabolism on endothelial cells, offering some insights into further research on the pathogenesis of cardiovascular diseases and corresponding therapeutic targets.
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页数：12
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