A case of transient existence of SARS-CoV-2 RNA in the respiratory tract with the absence of anti-SARS-CoV-2 antibody response

被引：14

作者：

Lin, Yi-Chun ^{[1
,2
]}

Cheng, Chien-Yu ^{[1
,3
]}

Chen, Cheng-Pin ^{[1
,4
]}

Cheng, Shu-Hsing ^{[1
,5
]}

Chang, Sui-Yuan ^{[6
,7
]}

Hsueh, Po-Ren ^{[7
,8
]}

机构：

[1] Taoyuan Gen Hosp, Dept Internal Med, Div Infect Dis, Minist Hlth & Welf, Taoyuan, Taiwan

[2] Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan

[3] Natl Yang Ming Univ, Sch Publ Hlth, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan

[5] Taipei Med Univ, Sch Publ Hlth, Taipei, Taiwan

[6] Natl Taiwan Univ, Dept Clin Lab Sci & Med Biotechnol, Coll Med, Taipei, Taiwan

[7] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Lab Med, Coll Med, Taipei, Taiwan

[8] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Coll Med, Taipei, Taiwan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 96卷

关键词：

COVID-19; SARS-CoV-2; Asymptomatic infection; Colonization; Contamination;

D O I：

10.1016/j.ijid.2020.05.070

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the case of a patient who had travelled to Japan and who presented mild respiratory symptoms during the COVID-19 outbreak period. There was transient existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in his oropharynx. The RNA was absent in the six respiratory specimens that were subsequently tested. An anti-SARS-CoV-2 antibody response was absent in the acute and convalescent sera. The reported case indicates that transient colonization of SARS-CoV-2 in the upper respiratory tract is possible without inciting any antibody response against the virus. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：464 / 466

页数：3

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