Biphasic Levodopa-Induced Freezing of Gait in Parkinson's Disease

被引：9

作者：

Nonnekes, Jorik ^{[1
,2
]}

Bloem, Bastiaan R. ^{[3
]}

机构：

[1] Radboud Univ Nijmegen, Ctr Expertise Parkinson & Movement Disorders, Donders Inst Brain Cognit & Behav, Med Ctr,Dept Rehabil, Nijmegen, Netherlands

[2] Sint Maartensklin, Dept Rehabil, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Expertise Parkinson & Movement Disorders, Med Ctr,Dept Neurol, Nijmegen, Netherlands

来源：

JOURNAL OF PARKINSONS DISEASE | 2020年 / 10卷 / 03期

关键词：

Gait; freezing of gait; levodopa; Parkinson's disease; parkinsonism; biphasic;

D O I：

10.3233/JPD-201997

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The relation between freezing of gait in Parkinson's disease and levodopa is complex. Here, we describe a new phenotype of freezing of gait, namely levodopa-induced freezing of gait with a biphasic pattern. Our observation supports the idea that freezing of gait might emerge because of a mismatch between cognitive/limbic loops and motor loops involved in gait control. Moreover, it underscores the importance of assessing the influence of dopaminergic medication in daily clinical practice, including objective assessment in all three dopaminergic states. The possibility of biphasic freezing will only emerge after such a comprehensive evaluation, and will have immediate therapeutic consequences.

引用

收藏

页码：1245 / 1248

页数：4

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