Management of recurrent and refractory Cushing disease

被引：35
作者：
Aghi, Manish K. [1 ]
机构：
[1] Univ Calif San Francisco, Calif Ctr Pituitary Disorders, San Francisco, CA 94143 USA
来源：
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM | 2008年 / 4卷 / 10期
关键词：
adrenalectomy; Cushing disease; ketoconazole; radiosurgery; transsphenoidal surgery;
D O I：
10.1038/ncpendmet0947
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cushing disease is most frequently caused by pituitary adenomas that secrete adrenocorticotrophic hormone. Transsphenoidal surgery is the treatment of choice in patients with these tumors because of reported remission rates of 69-93%. More challenging for neurosurgeons and endocrinologists, however, is management of the remaining patients whose Cushing disease is refractory to initial transsphenoidal surgery or recurs after initial remission. Here, we review the treatment options and latest surgical, medical, and radiosurgical advances for patients who have persistent or recurrent Cushing disease after transsphenoidal surgery.
引用
收藏
页码：560 / 568
页数：9
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