Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis

被引：9

作者：

Wang, Jing ^{[1
]}

Chen, Chun-Chi ^{[1
]}

Yang, Yunyun ^{[2
]}

Liu, Weidong ^{[1
]}

Ko, Tzu-Ping ^{[3
]}

Shang, Na ^{[1
]}

Hu, Xiangying ^{[1
,4
]}

Xie, Yonghua ^{[2
]}

Huang, Jian-Wen ^{[1
]}

Zhang, Yonghui ^{[2
]}

Guo, Rey-Ting ^{[1
]}

机构：

[1] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China

[2] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

[3] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan

[4] Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 495卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Aromatic prenyltransferase; Stigonematales; FamD1; Crystal structure; BIOGENESIS; AMBIGUINE; IDENTIFICATION; FISCHERINDOLE; DISCOVERY; SYSTEM; FAMILY; SUITE;

D O I：

10.1016/j.bbrc.2017.12.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

FamD1 is a novel CloQfflphB-family indole prenyltransferase which involves in hapalindole-type alkaloid biosynthesis. Here the native FamD1 structure and three protein-ligand complexes are analyzed to investigate the molecular basis of substrate binding and catalysis. FamD1 adopts a typical ABBA architecture of aromatic prenyltransferase, in which the substrate-binding chamber is found in the central beta barrel. The indole-containing acceptor substrate is bound adjacent to the prenyl donor. Based on the complex structures, a catalytic mechanism of FamD1 is proposed. Functional implications on the sister enzyme FamD2 are also discussed. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：1782 / 1788

页数：7

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