Association between hemolysis and albuminuria in adults with sickle cell anemia

被引：82

作者：

Day, Thomas G. ^{[2
]}

Drasar, Emma R. ^{[2
]}

Fulford, Tony ^{[3
]}

Sharpe, Claire C. ^{[4
]}

Thein, Swee Lay ^{[1
,2
]}

机构：

[1] Kings Coll London, Sch Med, James Black Ctr, London SE5 9NU, England

[2] Kings Coll Hosp London, Dept Haematol Med, London, England

[3] London Sch Hyg & Trop Med, MRC Int Nutr Grp, London WC1, England

[4] Kings Coll Hosp London, Dept Renal Med, London, England

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2012年 / 97卷 / 02期

基金：

英国医学研究理事会;

关键词：

sickle cell disease; nephropathy; hemolysis; kidney; RENAL-FAILURE; RISK-FACTORS; DISEASE; MORTALITY; PREVALENCE; DEATH;

D O I：

10.3324/haematol.2011.050336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell disease. While significant associations were found in HbSS and HbS beta(0) (sickle cell anemia) patients with and without controlling for covariates between hemolytic markers and albuminuria, the associations were not significant in patients with HbSC. Estimated glomerular filtration rate, a marker of renal function, correlated significantly with reticulocyte count and bilirubin. Alpha thalassemia, present in 34% of the sickle cell anaemia patients, had a protective effect against albuminuria in this group. Altogether, the incidence of hyperfiltration was 71% and microalbuminuria 37%, making nephropathy a common complication of sickle cell anemia.

引用

页码：201 / 205

页数：5

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