The connector between the kinase and RNase domains of IRE1α differentially controls the activities of this stress sensor

被引:0
|
作者
Ricci, Daniela [1 ,2 ]
Tutton, Stephen [1 ,2 ]
Chomistek, Steven [1 ,2 ]
Marrocco, Ilaria [1 ,2 ]
Ying, Mingjie [3 ]
Blumental, Daniel [1 ,2 ]
Eletto, Daniela [1 ,2 ]
Vargas, Jade [1 ,2 ]
Boyle, Sarah [1 ,2 ]
Fazelinia, Hossein [1 ,2 ]
Paton, James [3 ]
Paton, Adrienne [4 ]
Tang, Anthony [5 ]
Hu, Chih-Chi [5 ]
Gidalevitz, Tali [3 ]
Argon, Yair [1 ,2 ]
机构
[1] Childrens Hosp Philadelphia, Div Cell Pathol, Civ Ctr Blvd, Philadelphia, PA 19104 USA
[2] Univ Penn, Civ Ctr Blvd, Philadelphia, PA 19104 USA
[3] Drexel Univ, Dept Biol, Philadelphia, PA 19104 USA
[4] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia
[5] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA
来源
FASEB JOURNAL | 2020年 / 34卷
关键词
D O I
10.1096/fasebj.2020.34.s1.03046
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [1] RNase domains determine the functional difference between IRE1α and IRE1β
    Imagawa, Yusuke
    Hosoda, Akira
    Sasaka, Shin-ichi
    Tsuru, Akio
    Kohno, Kenji
    FEBS LETTERS, 2008, 582 (05): : 656 - 660
  • [2] A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress
    Dan, Han
    Upton, John-Paul
    Hagen, Andrew
    Callahan, Joseph
    Oakes, Scott A.
    Papa, Feroz R.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 365 (04) : 777 - 783
  • [3] Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress
    Bouchecareilh, Marion
    Higa, Arisa
    Fribourg, Sebastien
    Moenner, Michel
    Chevet, Eric
    FASEB JOURNAL, 2011, 25 (09): : 3115 - 3129
  • [4] The Bcl-2 family protein bid interacts with the ER stress sensor IRE1 to differentially modulate its RNase activity
    Bashir, Samirul
    Banday, Mariam
    Qadri, Ozaira
    Pal, Debnath
    Bashir, Arif
    Hilal, Nazia
    Altaf, Mohammad
    Fazili, Khalid Majid
    FEBS LETTERS, 2023, 597 (07) : 962 - 974
  • [5] IRE1 RNase controls CD95-mediated cell death
    Pelizzari-Raymundo, Diana
    Maltret, Victoria
    Nivet, Manon
    Pineau, Raphael
    Papaioannou, Alexandra
    Zhou, Xingchen
    Caradec, Flavie
    Martin, Sophie
    Le Gallo, Matthieu
    Avril, Tony
    Chevet, Eric
    Lafont, Elodie
    EMBO REPORTS, 2024, 25 (04) : 1792 - 1813
  • [6] Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
    Alexei V Korennykh
    Pascal F Egea
    Andrei A Korostelev
    Janet Finer-Moore
    Robert M Stroud
    Chao Zhang
    Kevan M Shokat
    Peter Walter
    BMC Biology, 9
  • [7] Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication
    Su, Airong
    Wang, Huanru
    Li, Yanlei
    Wang, Xiaohui
    Chen, Deyan
    Wu, Zhiwei
    VIRUSES-BASEL, 2017, 9 (09):
  • [8] Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
    Korennykh, Alexei V.
    Egea, Pascal F.
    Korostelev, Andrei A.
    Finer-Moore, Janet
    Stroud, Robert M.
    Zhang, Chao
    Shokat, Kevan M.
    Walter, Peter
    BMC BIOLOGY, 2011, 9
  • [9] Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers
    Dawes, Sam
    Hurst, Nicholas
    Grey, Gabriel
    Wieteska, Lukasz
    Wright, Nathan, V
    Manfield, Iain W.
    Hussain, Mohammed H.
    Kalverda, Arnout P.
    Lewandowski, Jozef R.
    Chen, Beining
    Zhuravleva, Anastasia
    LIFE SCIENCE ALLIANCE, 2024, 7 (10)
  • [10] The Oligomerization Status of IRE1α Kinase/RNase Determines Its Signaling Outputs Under Endoplasmic Reticulum Stress
    Oakes, Scott
    FASEB JOURNAL, 2020, 34