Efficient Palladium-Catalyzed Cross-Coupling Reaction of Alkynyl Halides with Organoboronic Acids under Aerobic Conditions

被引：14

作者：

Tang, Jian-Sheng ^{[1
,2
]}

Tian, Mi ^{[1
]}

Sheng, Wen-Bing ^{[1
]}

Guo, Can-Cheng ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

[2] Hunan First Normal Univ, Math & Sci Dept, Changsha 410205, Hunan, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 04期

关键词：

palladium; alkynyl halides; organoboronic acids; cross-coupling reaction; alkynes; TERMINAL ALKYNES; ARYLBORONIC ACIDS; SONOGASHIRA REACTIONS; LIGAND-FREE; BROMIDES; IODIDES; ENEDIYNE;

D O I：

10.1055/s-0031-1290159

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ligand-free palladium-catalyzed cross-coupling reaction of alkynyl halides with organoboronic acids under aerobic conditions has been developed. In the presence of bis(dibenzylideneacetone) palladium(0) and cesium carbonate, a variety of alkynyl halides (I, Br, and Cl) underwent the Suzuki-Miyaura cross-coupling reaction with organoboronic acids at room temperature to afford the corresponding unsymmetrical diarylalkynes in moderate to good yields. It is noteworthy that this is first report on the reaction of alkynyl chlorides with arylboronic acids.

引用

页码：541 / 546

页数：6

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