Biomarkers of Acute and Chronic Kidney Disease

被引：219

作者：

Zhang, William R. ^{[1
]}

Parikh, Chirag R. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Kidney Hlth Res Collaborat, San Francisco, CA 94121 USA

[2] Johns Hopkins Sch Med, Div Nephrol, Baltimore, MD 21287 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 | 2019年 / 81卷

关键词：

biomarkers; acute kidney injury; AKI; chronic kidney disease; CKD; kidney; MONOCYTE CHEMOATTRACTANT PROTEIN-1; EPIDERMAL-GROWTH-FACTOR; ACID-BINDING PROTEIN; GELATINASE-ASSOCIATED LIPOCALIN; ACUTE-RENAL-FAILURE; TNF RECEPTORS 1; ACUTE TUBULAR-NECROSIS; INJURY MOLECULE-1; FUNCTION DECLINE; GENE-EXPRESSION;

D O I：

10.1146/annurev-physiol-020518-114605

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The current unidimensional paradigm of kidney disease detection is incompatible with the complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Following insult, the kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Modern advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for assessing and characterizing kidney diseases. In this review, we highlight promising biomarkers of kidney tubular health that have strong underpinnings in the pathophysiology of kidney disease. These biomarkers have been applied to various specific clinical settings from the spectrum of acute to chronic kidney diseases, demonstrating the potential to improve patient care.

引用

页码：309 / 333

页数：25

共 148 条

[91] Soluble Tumor Necrosis Factor Receptor 1 and 2 Predict Outcomes in Advanced Chronic Kidney Disease: A Prospective Cohort Study [J].

Neirynck, Nathalie ;

Glorieux, Griet ;

Schepers, Eva ;

Verbeke, Francis ;

Vanholder, Raymond .

PLOS ONE, 2015, 10 (03)

[92] Biomarkers in acute and chronic kidney disease [J].

Nickolas, Thomas L. ;

Barasch, Jonathan ;

Devarajan, Prasad .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2008, 17 (02) :127-132

[93] NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease [J].

Nickolas, Thomas L. ;

Forster, Catherine S. ;

Sise, Meghan E. ;

Barasch, Nicholas ;

Sola-Del Valle, David ;

Viltard, Melanie ;

Buchen, Charles ;

Kupferman, Shlomo ;

Carnevali, Maria Luisa ;

Bennett, Michael ;

Mattei, Silvia ;

Bovino, Achiropita ;

Argentiero, Lucia ;

Magnano, Andrea ;

Devarajan, Prasad ;

Mori, Kiyoshi ;

Erdjument-Bromage, Hediye ;

Tempst, Paul ;

Allegri, Landino ;

Barasch, Jonathan .

KIDNEY INTERNATIONAL, 2012, 82 (06) :718-722

[94] Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes [J].

Niewczas, Monika A. ;

Gohda, Tomohito ;

Skupien, Jan ;

Smiles, Adam M. ;

Walker, William H. ;

Rosetti, Florencia ;

Cullere, Xavier ;

Eckfeldt, John H. ;

Doria, Alessandro ;

Mayadas, Tanya N. ;

Warram, James H. ;

Krolewski, Andrzej S. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (03) :507-515

[95]

Noris M, 1995, LAB INVEST, V73, P804

[96] Application of new acute kidney injury biomarkers in human randomized controlled trials [J].

Parikh, Chirag R. ;

Moledina, Dennis G. ;

Coca, Steven G. ;

Thiessen-Philbrook, Heather R. ;

Garg, Amit X. .

KIDNEY INTERNATIONAL, 2016, 89 (06) :1372-1379

[97] Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery [J].

Parikh, Chirag R. ;

Thiessen-Philbrook, Heather ;

Garg, Amit X. ;

Kadiyala, Deepak ;

Shlipak, Michael G. ;

Koyner, Jay L. ;

Edelstein, Charles L. ;

Devarajan, Prasad ;

Patel, Uptal D. ;

Zappitelli, Michael ;

Krawczeski, Catherine D. ;

Passik, Cary S. ;

Coca, Steven G. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (07) :1079-1088

[98] Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery [J].

Parikh, Chirag R. ;

Coca, Steven G. ;

Thiessen-Philbrook, Heather ;

Shlipak, Michael G. ;

Koyner, Jay L. ;

Wang, Zhu ;

Edelstein, Charles L. ;

Devarajan, Prasad ;

Patel, Uptal D. ;

Zappitelli, Michael ;

Krawczeski, Catherine D. ;

Passik, Cary S. ;

Swaminathan, Madhav ;

Garg, Amit X. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (09) :1748-1757

[99] Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery [J].

Parikh, Chirag R. ;

Devarajan, Prasad ;

Zappitelli, Michael ;

Sint, Kyaw ;

Thiessen-Philbrook, Heather ;

Li, Simon ;

Kim, Richard W. ;

Koyner, Jay L. ;

Coca, Steven G. ;

Edelstein, Charles L. ;

Shlipak, Michael G. ;

Garg, Amit X. ;

Krawczeski, Catherine D. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (09) :1737-1747

[100] Elevation of circulating TNF receptors 1 and 2 increases the risk of end-stage renal disease in American Indians with type 2 diabetes [J].

Paykov, Meda E. ;

Nelson, Robert G. ;

Knowler, William C. ;

Cheng, Yiling ;

Krolewski, Andrzej S. ;

Niewczas, Monika A. .

KIDNEY INTERNATIONAL, 2015, 87 (04) :812-819

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