Biomarkers of Acute and Chronic Kidney Disease

被引：216

作者：

Zhang, William R. ^{[1
]}

Parikh, Chirag R. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Kidney Hlth Res Collaborat, San Francisco, CA 94121 USA

[2] Johns Hopkins Sch Med, Div Nephrol, Baltimore, MD 21287 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 | 2019年 / 81卷

关键词：

biomarkers; acute kidney injury; AKI; chronic kidney disease; CKD; kidney; MONOCYTE CHEMOATTRACTANT PROTEIN-1; EPIDERMAL-GROWTH-FACTOR; ACID-BINDING PROTEIN; GELATINASE-ASSOCIATED LIPOCALIN; ACUTE-RENAL-FAILURE; TNF RECEPTORS 1; ACUTE TUBULAR-NECROSIS; INJURY MOLECULE-1; FUNCTION DECLINE; GENE-EXPRESSION;

D O I：

10.1146/annurev-physiol-020518-114605

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The current unidimensional paradigm of kidney disease detection is incompatible with the complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Following insult, the kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Modern advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for assessing and characterizing kidney diseases. In this review, we highlight promising biomarkers of kidney tubular health that have strong underpinnings in the pathophysiology of kidney disease. These biomarkers have been applied to various specific clinical settings from the spectrum of acute to chronic kidney diseases, demonstrating the potential to improve patient care.

引用

页码：309 / 333

页数：25

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