Androgen deprivation impairs memory in older men

被引:35
作者
Bussiere, JR
Beer, TM
Neiss, MB
Janowsky, JS
机构
[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Inst Canc, Dept Med, Portland, OR 97201 USA
关键词
androgen; testosterone; memory consolidation; hippocampus; aging;
D O I
10.1037/0735-7044.119.6.1429
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Androgen deprivation leads to a profound loss of synaptic density in the hippocampus and changes in learning and memory in animal models. The authors examined group differences in verbal memory between men on androgen deprivation therapy (ADT), a commonly used treatment for prostate cancer, and healthy men. The authors found that men on ADT have a specific impairment of retention but normal encoding and retrieval processes on a word list-learning task. Speed and accuracy for both perceptual and semantic encoding, as well as retrieval at a very short retention interval, were not affected; however, recognition fell to chance after a 2-min retention interval in men on ADT. Healthy men showed only moderate forgetting, and performance was still above chance at 12 min. This pattern of preserved encoding and retrieval but impaired retention suggests that androgens play a role in hippocampally mediated memory processes, possibly having a specific affect on consolidation.
引用
收藏
页码:1429 / 1437
页数:9
相关论文
共 80 条
[1]   Androgen receptor messenger ribonucleic acid in brains and pituitaries of male rhesus monkeys: Studies on distribution, hormonal control, and relationship to luteinizing hormone secretion [J].
Abdelgadir, SE ;
Roselli, CE ;
Choate, JVA ;
Resko, JA .
BIOLOGY OF REPRODUCTION, 1999, 60 (05) :1251-1256
[2]   Gonadectomy in adult life increases tyrosine hydroxylase immunoreactivity in the prefrontal cortex and decreases open field activity in male rats [J].
Adler, A ;
Vescovo, P ;
Robinson, JK ;
Kritzer, MF .
NEUROSCIENCE, 1999, 89 (03) :939-954
[3]   One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men [J].
Almeida, OP ;
Waterreus, A ;
Spry, N ;
Flicker, L ;
Martins, RN .
PSYCHONEUROENDOCRINOLOGY, 2004, 29 (08) :1071-1081
[4]   New insights into the regulation and function of brain estrogen synthase (aromatase) [J].
Balthazart, J ;
Ball, GF .
TRENDS IN NEUROSCIENCES, 1998, 21 (06) :243-249
[5]   Cognitive function and endogenous sex hormones in older women [J].
Barrett-Connor, E ;
Goodman-Gruen, D .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1999, 47 (11) :1289-1293
[6]   Endogenous sex hormones and cognitive function in older men [J].
Barrett-Connor, E ;
Goodman-Gruen, D ;
Patay, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10) :3681-3685
[7]   Recovery after prolonged sleep deprivation:: Residual effects of slow-release caffeine on recovery sleep, sleepiness and cognitive functions [J].
Beaumont, M ;
Batéjat, D ;
Coste, O ;
Doireau, P ;
Chauffard, F ;
Enslen, M ;
Lagarde, D ;
Pierard, C .
NEUROPSYCHOBIOLOGY, 2005, 51 (01) :16-27
[8]  
BEER TM, 2006, J UROLOGY, V175
[9]   Androgen receptor mRNA expression in the human hippocampus [J].
Beyenburg, S ;
Watzka, M ;
Clusmann, H ;
Blümcke, I ;
Bidlingmaier, F ;
Elger, CE ;
Stoffel-Wagner, B .
NEUROSCIENCE LETTERS, 2000, 294 (01) :25-28
[10]   Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats [J].
Bimonte-Nelson, HA ;
Singleton, RS ;
Nelson, ME ;
Eckman, CB ;
Barber, J ;
Scott, TY ;
Granholm, ACE .
EXPERIMENTAL NEUROLOGY, 2003, 181 (02) :301-312