Lipoprotein(a): A missing culprit in the management of athero-thrombosis?

被引：73

作者：

Ferretti, Gianna ^{[1
]}

Bacchetti, Tiziana ^{[2
]}

Johnston, Thomas P. ^{[3
]}

Banach, Maciej ^{[4
,5
]}

Pirro, Matteo ^{[6
]}

Sahebkar, Amirhossein ^{[7
,8
]}

机构：

[1] Polytech Univ Marche, Dept Clin Sci DISCO, Marche, Italy

[2] Polytech Univ Marche, Dept Life & Environm Sci DISVA, Marche, Italy

[3] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64110 USA

[4] Med Univ Lodz, Dept Hypertens, WAM Univ Hosp Lodz, Lodz, Poland

[5] PMMHRI, Lodz, Poland

[6] Univ Perugia, Unit Internal Med Angiol & Arteriosclerosis Dis, Dept Med, Perugia, Italy

[7] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran

[8] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 04期

关键词：

apolipoprotein(a); atherosclerosis; dyslipidemia; lipoprotein(a); oxidized phospholipids; thrombosis; LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE TRANSFER PROTEIN; HORMONE REPLACEMENT THERAPY; OXIDIZED PHOSPHOLIPIDS; CARDIOVASCULAR-DISEASE; PLASMA LIPOPROTEIN(A); FAMILIAL HYPERCHOLESTEROLEMIA; REDUCES LIPOPROTEIN(A); APOLIPOPROTEIN(A) GENE; PLASMINOGEN-ACTIVATOR;

D O I：

10.1002/jcp.26050

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lipoprotein(a) Lp(a) is a cholesterol-rich, LDL-like particle that is independently associated with an increased risk for ischemic heart disease, atherosclerosis, thrombosis, and stroke. Genetic variation in the Lp(a) locus and some other genes related to Lp(a) synthesis and metabolism play a critical role in regulating plasma Lp(a) levels. The pathophysiological potential of Lp(a) is related to proatherogenic and prothrombotic effects on the vasculature. Different molecular mechanisms underlying the atherothrombotic potential of Lp(a), free apolipoprotein(a), and oxidized-Lp(a) have been proposed. However, plasma Lp(a) assay is complicated by problems associated with quantification and standardization owing to the polymorphic nature of this lipoprotein. This review has focused on the physicochemical properties of Lp(a), the genetic aspects of Lp(a), the need for accurate determination of Lp(a), the synthesis, and recent findings on metabolism of Lp(a). Lastly, the patho-physiological mechanisms by which Lp(a) may increase athero-thrombosis and an overview on the therapeutic modalities to interfere with Lp(a) are summarized.

引用

页码：2966 / 2981

页数：16

共 101 条

[1] Relationship of Apolipoproteins A-1 and B, and Lipoprotein(a) to Cardiovascular Outcomes The AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglyceride and Impact on Global Health Outcomes) [J].

Albers, John J. ;

Slee, April ;

O'Brien, Kevin D. ;

Robinson, Jennifer G. ;

Kashyap, Moti L. ;

Kwiterovich, Peter O., Jr. ;

Xu, Ping ;

Marcovina, Santica M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (17) :1575-1579

[2] The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: A systematic review and meta-analysis [J].

Anagnostis, Panagiotis ;

Galanis, Petros ;

Chatzistergiou, Vasileia ;

Stevenson, John C. ;

Godsland, Ian F. ;

Lambrinoudaki, Irene ;

Theodorou, Mamas ;

Goulis, Dimitrios G. .

MATURITAS, 2017, 99 :27-36

[3] Apolipoprotein(a): Structure-function relationship at the lysine-binding site and plasminogen activator cleavage site [J].

Angles-Cano, E ;

Rojas, G .

BIOLOGICAL CHEMISTRY, 2002, 383 (01) :93-99

[4]

Anglés-Cano E, 2001, ANN NY ACAD SCI, V936, P261

[5] The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor [J].

Argraves, KM ;

Kozarsky, KF ;

Fallon, JT ;

Harpel, PC ;

Strickland, DK .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (09) :2170-2181

[6] Prediction of Cardiovascular Events in Statin-Treated Stable Coronary Patients of the Treating to New Targets Randomized Controlled Trial by Lipid and Non-Lipid Biomarkers [J].

Arsenault, Benoit J. ;

Barter, Philip ;

DeMicco, David A. ;

Bao, Weihang ;

Preston, Gregory M. ;

LaRosa, John C. ;

Grundy, Scott M. ;

Deedwania, Prakash ;

Greten, Heiner ;

Wenger, Nanette K. ;

Shepherd, James ;

Waters, David D. ;

Kastelein, John J. P. .

PLOS ONE, 2014, 9 (12)

[7] EUGLOBULIN CLOT LYSIS INDUCED BY TISSUE-TYPE PLASMINOGEN-ACTIVATOR IN SUBJECTS WITH INCREASED LEVELS AND DIFFERENT ISOFORMS OF LIPOPROTEIN (A) [J].

AZNAR, J ;

ESTELLES, A ;

BRETO, M ;

ESPANA, F .

THROMBOSIS RESEARCH, 1993, 72 (05) :459-465

[8] A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma [J].

Bergmark, Claes ;

Dewan, Asheesh ;

Orsoni, Alexina ;

Merki, Esther ;

Miller, Elizabeth R. ;

Shin, Min-Jeong ;

Binder, Christoph J. ;

Horkko, Sohvi ;

Krauss, Ronald M. ;

Chapman, M. John ;

Witztum, Joseph L. ;

Tsimikas, Sotirios .

JOURNAL OF LIPID RESEARCH, 2008, 49 (10) :2230-2239

[9] Thematic Review Series: Lipoprotein (a): Coming of Age at Last Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease? [J].

Boffa, Michael B. ;

Koschinsky, Marlys L. .

JOURNAL OF LIPID RESEARCH, 2016, 57 (05) :745-757

[10] Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a] [J].

Cain, WJ ;

Millar, JS ;

Himebauch, AS ;

Tietge, UJF ;

Maugeais, C ;

Usher, D ;

Rader, DJ .

JOURNAL OF LIPID RESEARCH, 2005, 46 (12) :2681-2691

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