Poly(L-lactide) Nanoparticles via Ring-Opening Polymerization in Non-aqueous Emulsion

被引：19

作者：

Dorresteijn, Robert ^{[1
]}

Haschick, Robert ^{[2
]}

Klapper, Markus ^{[1
]}

Muellen, Klaus ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

[2] BASF SE, D-67056 Ludwigshafen, Germany

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2012年 / 213卷 / 19期

关键词：

emulsion polymerization; nanoparticles; polyesters; ring-opening polymerization; N-HETEROCYCLIC CARBENES; LIVING POLYMERIZATION; ISOPROPOXIDE; COPOLYMERS; PARTICLES; CATALYSTS; LACTIDE; BLOCK; TOOL;

D O I：

10.1002/macp.201200345

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The preparation of poly(L-lactide) nanoparticles via ring-opening polymerization (ROP) of L-lactide is conducted in non-aqueous emulsion. In this process, acetonitrile is dispersed in either cyclohexane or n-hexane as the continuous phase and stabilized by a PI-b-PEO, respectively, a PI-b-PS copolymer as emulsifier. The air and moisture sensitive N-heterocyclic carbene 1,3-bis(2,4,6-trimethylphenyl)-2-ididazolidinylidene (SIMes) catalyzes the polymerization of L-lactide at ambient temperatures. Spherical poly(L-lactide) nanoparticles with an average diameter of 70 nm and a tunable molecular weight are generated. Hence, the non-aqueous emulsion technique demonstrates its good applicability toward the generation of well-defined poly(L-lactide) nanoparticles under very mild conditions.

引用

页码：1996 / 2002

页数：7

共 35 条

[1] First example of N-heterocyclic carbenes as catalysts for living polymerization:: Organocatalytic ring-opening polymerization of cyclic esters [J].

Connor, EF ;

Nyce, GW ;

Myers, M ;

Möck, A ;

Hedrick, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (06) :914-915

[2] Alcohol adducts of N-heterocyclic carbenes:: Latent catalysts for the thermally-controlled living polymerization of cyclic esters [J].

Coulembier, Olivier ;

Lohmeijer, Bas G. G. ;

Dove, Andrew P. ;

Pratt, Russell C. ;

Mespouille, Laetitia ;

Culkin, Darcy A. ;

Benight, Stephanie J. ;

Dubois, Philippe ;

Waymouth, Robert M. ;

Hedrick, James L. .

MACROMOLECULES, 2006, 39 (17) :5617-5628

[3] Single-component catalyst/initiators for the organocatalytic ring-opening polymerization of lactide [J].

Csihony, S ;

Culkin, DA ;

Sentman, AC ;

Dove, AP ;

Waymouth, RM ;

Hedrick, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (25) :9079-9084

[4]

Culkin D.A., 2007, Angew. Chem, V119, P2681, DOI [10.1002/ange.200604740, DOI 10.1002/ANGE.200604740]

[5] Controlled ring-opening polymerization of lactide and glycolide [J].

Dechy-Cabaret, O ;

Martin-Vaca, B ;

Bourissou, D .

CHEMICAL REVIEWS, 2004, 104 (12) :6147-6176

[6] Fundamental solution and single-chain properties of polylactides [J].

Dorgan, JR ;

Janzen, J ;

Knauss, DM ;

Hait, SB ;

Limoges, BR ;

Hutchinson, MH .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2005, 43 (21) :3100-3111

[7] Thiourea-based bifunctional organocatalysis: Supramolecular recognition for living polymerization [J].

Dove, AP ;

Pratt, RC ;

Lohmeijer, BGG ;

Waymouth, RM ;

Hedrick, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (40) :13798-13799

[8] Molecularly Imprinted Nanospheres by Nonaqueous Emulsion Polymerization [J].

Dvorakova, Gita ;

Haschick, Robert ;

Chiad, Khalid ;

Klapper, Markus ;

Muellen, Klaus ;

Biffis, Andrea .

MACROMOLECULAR RAPID COMMUNICATIONS, 2010, 31 (23) :2035-2040

[9] A literature review of poly(lactic acid) [J].

Garlotta, D .

JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2001, 9 (02) :63-84

[10] A General Synthetic Approach for Obtaining Cationic and Anionic Inorganic Nanoparticles via Encapsulation in Amphiphilic Copolymers [J].

Geidel, C. ;

Schmachtel, S. ;

Riedinger, A. ;

Pfeiffer, C. ;

Muellen, K. ;

Klapper, M. ;

Parak, W. J. .

SMALL, 2011, 7 (20) :2929-2934

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