OBJECTIVE. The purpose of this article is to discuss radiation dose during CT-guided interventions and to explain how radiologists can modify technical factors to minimize radiation doses. Scanner-displayed indexes of radiation exposure that are available during the procedure will be defined to increase awareness about CT radiation dose reduction during interventional procedures. CONCLUSION. CT-guided fluoroscopic procedures are safe and effective methods of directed intervention; however, the increasing use of medical radiation is an important consideration. The appropriate use of imaging with an acceptable risk must be considered in every case. During CT-guided interventions, scanner parameters that can be used as a guide for effective dose management, including the CT dose index and dose-length product, are readily displayed. These parameters can be adjusted by modifying the longitudinal scan length, number of scans, and tube current-exposure time product (milliampere x second [mAs]). A team approach to radiation dose reduction will work the best.