A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)

A novel mixed platinum(II) complex with general formula [Pt(PPh3)(2)(L-1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (H-1, C-13 and P-31) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C-H center dot center dot center dot O and C-H center dot center dot center dot F hydrogen bonds, and C-H center dot center dot center dot pi stacking interactions. The steric congestion of ligands is described by "exact" cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C-H center dot center dot center dot Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.