Ebola virus (EBOV) remains one of the most lethal transmissible infections and is responsible for high fatality rates and substantial morbidity during sporadic outbreaks. With increasing human incursions into endemic regions and the reported possibility of airborne transmission, EBOV is a high-priority public health threat for which no preventive or therapeutic options are currently available. Recent studies have demonstrated that cocktails of monoclonal antibodies are effective at preventing morbidity and mortality in nonhuman primates (NHPs) when administered as a post-exposure prophylactic within 1 or 2 days of challenge. To test whether one of these cocktails (MB-003) demonstrates efficacy as a therapeutic (after the onset of symptoms), we challenged NHPs with EBOV and initiated treatment upon confirmation of infection according to a diagnostic protocol for U.S. Food and Drug Administration Emergency Use Authorization and observation of a documented fever. Of the treated animals, 43% survived challenge, whereas both the controls and all historical controls with the same challenge stock succumbed to infection. These results represent successful therapy of EBOV infection in NHPs.
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Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Geisbert, Thomas W.
;
Lee, Amy C. H.
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Lee, Amy C. H.
;
Robbins, Marjorie
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Robbins, Marjorie
;
Geisbert, Joan B.
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Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Geisbert, Joan B.
;
Honko, Anna N.
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USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Honko, Anna N.
;
Sood, Vandana
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Sood, Vandana
;
Johnson, Joshua C.
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USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Johnson, Joshua C.
;
de Jong, Susan
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
de Jong, Susan
;
Tavakoli, Iran
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Tavakoli, Iran
;
Judge, Adam
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Judge, Adam
;
Hensley, Lisa E.
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USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Hensley, Lisa E.
;
MacLachlan, Ian
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Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
机构:
Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USACtr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA
MacNeil, Adam
;
Rollin, Pierre E.
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Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USACtr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA
机构:
Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Geisbert, Thomas W.
;
Lee, Amy C. H.
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h-index: 0
机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Lee, Amy C. H.
;
Robbins, Marjorie
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机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Robbins, Marjorie
;
Geisbert, Joan B.
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机构:
Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Geisbert, Joan B.
;
Honko, Anna N.
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机构:
USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Honko, Anna N.
;
Sood, Vandana
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h-index: 0
机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Sood, Vandana
;
Johnson, Joshua C.
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h-index: 0
机构:
USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Johnson, Joshua C.
;
de Jong, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
de Jong, Susan
;
Tavakoli, Iran
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h-index: 0
机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Tavakoli, Iran
;
Judge, Adam
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h-index: 0
机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Judge, Adam
;
Hensley, Lisa E.
论文数: 0引用数: 0
h-index: 0
机构:
USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USABoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
Hensley, Lisa E.
;
MacLachlan, Ian
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h-index: 0
机构:
Tekmira Pharmaceut, Burnaby, BC, CanadaBoston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA
机构:
Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USACtr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA
MacNeil, Adam
;
Rollin, Pierre E.
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h-index: 0
机构:
Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USACtr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA