Blood Compatibility Evaluation of Elastic Gelatin Gel from Salmon Collagen

被引：8

作者：

Nagai, Nobuhiro ^{[1
]}

Kubota, Ryosuke ^{[2
]}

Okahashi, Ryohei ^{[2
]}

Munekata, Masanobu ^{[2
]}

机构：

[1] Hokkaido Univ, Creat Res Initiat Sousei CRIS, Kita Ku, Sapporo, Hokkaido 0010021, Japan

[2] Hokkaido Univ, Grad Sch Engn, Div Biotechnol & Macromol Chem, Kita Ku, Sapporo, Hokkaido 0608628, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2008年 / 106卷 / 04期

关键词：

blood compatibility; elastic gel; platelet adhesion; salmon collagen;

D O I：

10.1263/jbb.106.412

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Blood compatibility of a novel elastic gelatin gel (e-gel) from salmon collagen was evaluated. After a 10-min incubation of the e-gel with rat whole blood, there was a macroscopically small thrombus formation on the e-gel. Microscopic observation revealed that few platelets had adhered to the e-gel. Furthermore, the platelet adhesion rate was markedly lower on the e-gel compared to collagen-coated and fibrinogen-coated surfaces. Comparable results were obtained with re-crosslinked e-gel. In conclusion, the e-gel demonstrated good blood compatibility.

引用

页码：412 / 415

页数：4

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