Blood Compatibility Evaluation of Elastic Gelatin Gel from Salmon Collagen

被引：7
|
作者：
Nagai, Nobuhiro [1 ]
Kubota, Ryosuke [2 ]
Okahashi, Ryohei [2 ]
Munekata, Masanobu [2 ]
机构：
[1] Hokkaido Univ, Creat Res Initiat Sousei CRIS, Kita Ku, Sapporo, Hokkaido 0010021, Japan
[2] Hokkaido Univ, Grad Sch Engn, Div Biotechnol & Macromol Chem, Kita Ku, Sapporo, Hokkaido 0608628, Japan
来源：
JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2008年 / 106卷 / 04期
关键词：
blood compatibility; elastic gel; platelet adhesion; salmon collagen;
D O I：
10.1263/jbb.106.412
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Blood compatibility of a novel elastic gelatin gel (e-gel) from salmon collagen was evaluated. After a 10-min incubation of the e-gel with rat whole blood, there was a macroscopically small thrombus formation on the e-gel. Microscopic observation revealed that few platelets had adhered to the e-gel. Furthermore, the platelet adhesion rate was markedly lower on the e-gel compared to collagen-coated and fibrinogen-coated surfaces. Comparable results were obtained with re-crosslinked e-gel. In conclusion, the e-gel demonstrated good blood compatibility.
引用
收藏
页码：412 / 415
页数：4
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