Rational design of non-hydroxamate histone deacetylase inhibitors

被引：27

作者：

Suzuki, T ^{[1
]}

Miyata, N ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 05期

关键词：

histone deacetylase; inhibitor; hydroxamic acid; non-hydroxamate; zinc enzyme; rational drug design; anticancer agent;

D O I：

10.2174/138955706776876186

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several non-hydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.

引用

页码：515 / 526

页数：12

共 57 条

[1] Histone deacetylase inhibitors: From chromatin remodeling to experimental cancer therapeutics
Arts, J
de Schepper, S
Van Emelen, K
[J]. CURRENT MEDICINAL CHEMISTRY, 2003, 10 (22) : 2343 - 2350
[2] THE PROOLIGONUCLEOTIDE APPROACH .1. ESTERASE-MEDIATED REVERSIBILITY OF DITHYMIDINE-S-ALKYL-PHOSPHOROTHIOLATES TO DITHYMIDINE PHOSPHOROTHIOATES
BARBER, I
RAYNER, B
IMBACH, JL
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (06) : 563 - 568
[3] Histone modifications in transcriptional regulation
Berger, SL
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) : 142 - 148
[4] Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: Synthesis and antiproliferative evaluation
Bouchain, G
Delorme, D
[J]. CURRENT MEDICINAL CHEMISTRY, 2003, 10 (22) : 2359 - 2372
[5] Short-Chain Fatty Acid Inhibitors of Histone Deacetylases: Promising Anticancer Therapeutics?
Chen, James S.
Faller, Douglas V.
Spanjaard, Remco A.
[J]. CURRENT CANCER DRUG TARGETS, 2003, 3 (03) : 219 - 236
[6] THE COMPLEX BETWEEN CARBOXYPEPTIDASE-A AND A POSSIBLE TRANSITION-STATE ANALOG - MECHANISTIC INFERENCES FROM HIGH-RESOLUTION X-RAY STRUCTURES OF ENZYME-INHIBITOR COMPLEXES
CHRISTIANSON, DW
LIPSCOMB, WN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (16) : 4998 - 5003
[7] CARBOXYPEPTIDASE-A
CHRISTIANSON, DW
LIPSCOMB, WN
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1989, 22 (02) : 62 - 69
[8] Histone deacetylase inhibitors: The Abbott experience
Curtin, M
Glaser, K
[J]. CURRENT MEDICINAL CHEMISTRY, 2003, 10 (22) : 2373 - 2392
[9] Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
Finnin M.S.
Donigian J.R.
Cohen A.
Richon V.M.
Rifkind R.A.
Marks P.A.
Breslow R.
Pavletich N.P.
[J]. Nature, 1999, 401 (6749) : 188 - 193
[10] Trifluoromethyl ketones as inhibitors of histone deacetylase
Frey, RR
Wada, CK
Garland, RB
Curtin, ML
Michaelides, MR
Li, JL
Pease, LJ
Glaser, KB
Marcotte, PA
Bouska, JJ
Murphy, SS
Davidsen, SK
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (23) : 3443 - 3447

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