RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

被引：234

作者：

Moraes-Vieira, Pedro M. ^{[1
,2
]}

Yore, Mark M. ^{[1
,2
]}

Dwyer, Peter M. ^{[1
,2
]}

Syed, Ismail ^{[1
,2
]}

Aryal, Pratik ^{[1
,2
]}

Kahn, Barbara B. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

CELL METABOLISM | 2014年 / 19卷 / 03期

基金：

美国国家卫生研究院;

关键词：

RETINOL-BINDING-PROTEIN; DIET-INDUCED OBESITY; REGULATORY T-CELLS; DENDRITIC CELLS; MACROPHAGE ACTIVATION; UNIQUE POPULATION; PLASMA RETINOL; OB/OB MICE; EXPRESSION; RETINOL-BINDING-PROTEIN-4;

D O I：

10.1016/j.cmet.2014.01.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Insulin resistance is a major cause of diabetes and is highly associated with adipose tissue (AT) inflammation in obesity. RBP4, a retinol transporter, is elevated in insulin resistance and contributes to increased diabetes risk. We aimed to determine the mechanisms for RBP4-induced insulin resistance. Here we show that RBP4 elevation causes AT inflammation by activating innate immunity that elicits an adaptive immune response. RBP4-overexpressing mice (RBP4-Ox) are insulin resistant and glucose intolerant and have increased AT macrophage and CD4 T cell infiltration. In RBP4-Ox, AT CD206(+) macrophages express proinflammatory markers and activate CD4 T cells while maintaining alternatively activated macrophage markers. These effects result from direct activation of AT antigen-presenting cells (APCs) by RBP4 through a JNK-dependent pathway. Transfer of RBP4-activated APCs into normal mice is sufficient to induce AT inflammation, insulin resistance, and glucose intolerance. Thus, RBP4 causes insulin resistance, at least partly, by activating AT APCs that induce CD4 T cell Th1 polarization and AT inflammation.

引用

页码：512 / 526

页数：15

共 53 条

[1] Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: Association with subclinical inflammation [J].