Regulatory T cells and inflammatory bowel disease

被引：230
作者：
Groux, H
Powrie, F
机构：
[1] Hop Archet, INSERM U343, F-06200 Nice, France
[2] Univ Oxford, John Radcliffe Hosp, Dept Surg, Oxford OX3 9DU, England
来源：
IMMUNOLOGY TODAY | 1999年 / 20卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0167-5699(99)01510-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have identified interleukin 10 as a differentiation factor for a novel subset of immune suppressive regulatory T cells. Here, Herve Groux and Fiona Powrie discuss the role that these cells play in the regulation of immune responses to enteric antigens and suggest that a deficiency in these cells might be involved in the pathogenesis of inflammatory bowel disease.
引用
收藏
页码：442 / 446
页数：5
相关论文
共 47 条
[1]  
Aranda R, 1997, J IMMUNOL, V158, P3464
[2]   INTERLEUKIN-10 BUT NOT INTERLEUKIN-4 IS A NATURAL SUPPRESSANT OF CUTANEOUS INFLAMMATORY RESPONSES [J].
BERG, DJ ;
LEACH, MW ;
KUHN, R ;
RAJEWSKY, K ;
MULLER, W ;
DAVIDSON, NJ ;
RENNICK, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) :99-108
[3]  
Bregenholt S, 1998, EUR J IMMUNOL, V28, P379, DOI 10.1002/(SICI)1521-4141(199801)28:01<379::AID-IMMU379>3.0.CO
[4]  
2-X
[5]   Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo [J].
Buer, J ;
Lanoue, A ;
Franzke, A ;
Garcia, C ;
von Boehmer, H ;
Sarukhan, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) :177-183
[6]   B7-1 EXPRESSION OF LANGERHANS CELLS IS UP-REGULATED BY PROINFLAMMATORY CYTOKINES, AND IS DOWN-REGULATED BY INTERFERON-GAMMA OR BY INTERLEUKIN-10 [J].
CHANG, CH ;
FURUE, M ;
TAMAKI, K .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (02) :394-398
[7]   REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS [J].
CHEN, YH ;
KUCHROO, VK ;
INOBE, J ;
HAFLER, DA ;
WEINER, HL .
SCIENCE, 1994, 265 (5176) :1237-1240
[8]  
Claesson MH, 1999, J IMMUNOL, V162, P3702
[9]   CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice:: Increased T helper cell type 1 response and ability to transfer disease [J].
Cong, YZ ;
Brandwein, SL ;
McCabe, RP ;
Lazenby, A ;
Birkenmeier, EH ;
Sundberg, JP ;
Elson, CO .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06) :855-864
[10]  
DE WMR, 1991, J EXP MED, V174, P1209
12345