Asymmetric Intermolecular Heck Reaction of Aryl Halides

被引：130

作者：

Wu, Chunlin ^{[1
]}

Zhou, Jianrong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

QUATERNARY CARBON CENTERS; ELECTRON-RICH OLEFINS; SUBSTITUTED (S)-PHENYLPIPERIDINES; LIGANDS; ENANTIOSELECTIVITY; CYCLIZATION; ARYLATION; ALCOHOLS; CATALYSIS; BINAP(O);

D O I：

10.1021/ja412277z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The asymmetric intermolecular Heck reaction has been limited to aryl and vinyl triflates. Herein, we extend the reaction to aryl and vinyl bromides. Various cyclic olefins coupled with high enantioselectivity. Only bisphosphine oxides on a Spiro backbone formed highly stereoselective Pd catalysts. The use of alcoholic solvents and alkylammonium salts were essential to promote halide dissociation from neutral arylpalladium complexes.

引用

页码：650 / 652

页数：3

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