Long-Range Interactions in Nonsense-Mediated mRNA Decay Are Mediated by Intrinsically Disordered Protein Regions

被引：7

作者：

Kalmar, Lajos ^{[1
]}

Acs, Veronika ^{[1
]}

Silhavy, Daniel ^{[2
]}

Tompa, Peter ^{[1
,3
,4
]}

机构：

[1] Hungarian Acad Sci, Res Ctr Nat Sci, Inst Enzymol, H-1113 Budapest, Hungary

[2] Agr Biotechnol Ctr, H-2100 Godollo, Hungary

[3] VIB, Dept Biol Struct, B-1050 Brussels, Belgium

[4] Vrije Univ Brussel, B-1050 Brussels, Belgium

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2012年 / 424卷 / 3-4期

基金：

匈牙利科学研究基金会;

关键词：

nonsense-mediated decay; protein disorder; fly-casting; long-range interaction; EXON JUNCTION COMPLEX; WEB SERVER; RECRUITMENT; TRANSLATION; MACHINERY; UPF1;

D O I：

10.1016/j.jmb.2012.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：125 / 131

页数：7

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