Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

被引：6

作者：

van der Wildt, Berend ^{[1
]}

Shen, Bin ^{[1
]}

Chin, Frederick T. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Radiol, MIPS, 1201 Welch Rd,PS049, Stanford, CA 94305 USA

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 21期

关键词：

ANGIOTENSIN-II; CONVERSION; MONOXIDE; ANTAGONIST; NONPEPTIDE; PRESSURE; POTENT;

D O I：

10.1039/c8cc09661a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [C-11] CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

引用

页码：3124 / 3127

页数：4

共 25 条

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