Long non-coding RNA MALAT1 regulates BLCAP mRNA expression through binding to miR-339-5p and promotes poor prognosis in breast cancer

被引:50
|
作者
Zheng, Liuhong [1 ]
Zhang, Yuhan [1 ]
Fu, Yajun [3 ]
Gong, Hangdi [2 ]
Guo, Jianjun [1 ]
Wu, Kangjing [1 ]
Jia, Qiaojun [1 ]
Ding, Xianfeng [1 ]
机构
[1] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou 310018, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310012, Zhejiang, Peoples R China
[3] Zhejiang Sci Tech Univ, Sch Clin, Hangzhou 310018, Zhejiang, Peoples R China
基金
浙江省自然科学基金;
关键词
MECHANISM; INVASION; PATHWAY;
D O I
10.1042/BSR20181284
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human genome transcribes a large amount of non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs. LncRNAs and microRNAs have been shown to play a critical regulatory role in tumorigenesis and progression. Competitive endogenous RNAs (ceRNAs) affect other RNAs transcription through competitively binding to common microRNAs (miRNAs). MALAT1 is a typical lncRNA that is markedly up-regulated in breast cancer. However, current understanding of the involvement of MALAT1 in breast cancer development and prognosis remains unclear. In the present study, the expression of MALAT1 in clinical samples of breast cancer tissues was found to be significantly up-regulated that was consistent with the result based on the dataset of the Cancer Genome Atlas (TCGA) at cBioportal. A negative correlation between overall survival and the expression of MALAT1 was statistically significant in the group of diagnosis age below 60 or in the group of infiltrating ductal carcinoma analyzed by TCGA database, which declared that MALAT1 might be a potentially useful prognostic factor. Furthermore, the combination of bioinformatics prediction with experimental verifications indicated that lncRNA MALAT1 can regulate BLCAP mRNA expression through binding to miR-339-5p.
引用
收藏
页数:12
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