New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities

被引：14

作者：

Zhang, Lei ^{[1
,2
,3
]}

Lin, Hai-Qing ^{[4
]}

Li, Gui-Sheng ^{[1
]}

Yue, Xi-Dian ^{[1
]}

Dai, Sheng-Jun ^{[1
,2
,3
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

[4] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250011, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 20期

关键词：

11,12-O-isopropylidenesolajiangxin F; Solanaceae; cytotoxic activity; sesquiterpenoid; septemlobin D; Solanum septemlobum; LYRATUM;

D O I：

10.1080/14786419.2015.1010164

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new sesquiterpenoid derivatives, attributable to eudesmane-type (1-2, named septemlobin D and 11,12-O-isopropylidenesolajiangxin F), were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D-NMR (H-1-H-1 COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.0-7.3 mu M.

引用

页码：1889 / 1893

页数：5

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