Nondisjunction in Favor of a Chromosome: The Mechanism of Rye B Chromosome Drive during Pollen Mitosis

被引:63
作者
Banaei-Moghaddam, Ali M. [1 ]
Schubert, Veit [1 ]
Kumke, Katrin [1 ]
Weiss, Oda [1 ]
Klemme, Sonja [1 ]
Nagaki, Kiyotaka [2 ]
Macas, Jiri [3 ]
Gonzalez-Sanchez, Monica [4 ]
Heredia, Victoria [4 ]
Gomez-Revilla, Diana [4 ]
Gonzalez-Garcia, Miriam [4 ]
Vega, Juan M. [4 ]
Puertas, Maria J. [4 ]
Houben, Andreas [1 ]
机构
[1] Leibniz Inst Plant Genet & Crop Plant Res, D-06466 Gatersleben, Germany
[2] Okayama Univ, Inst Plant Sci & Resources, Kurashiki, Okayama 7100046, Japan
[3] Acad Sci Czech Republ, Inst Plant Mol Biol, Ctr Biol, CR-37005 Ceske Budejovice, Czech Republic
[4] Univ Complutense, Fac Biol, Dept Genet, E-28040 Madrid, Spain
关键词
SECALE-CEREALE; MEIOTIC DRIVE; SUPERNUMERARY CHROMOSOMES; RETROTRANSPOSON FAMILY; ACCESSORY CHROMOSOMES; REPETITIVE DNA; TAPETAL CELLS; COMMON WHEAT; MAIZE; HETEROCHROMATIN;
D O I
10.1105/tpc.112.105270
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
B chromosomes (Bs) are supernumerary components of the genome and do not confer any advantages on the organisms that harbor them. The maintenance of Bs in natural populations is possible by their transmission at higher than Mendelian frequencies. Although drive is the key for understanding B chromosomes, the mechanism is largely unknown. We provide direct insights into the cellular mechanism of B chromosome drive in the male gametophyte of rye (Secale cereale). We found that nondisjunction of Bs is accompanied by centromere activity and is likely caused by extended cohesion of the B sister chromatids. The B centromere originated from an A centromere, which accumulated B-specific repeats and rearrangements. Because of unequal spindle formation at the first pollen mitosis, nondisjoined B chromatids preferentially become located toward the generative pole. The failure to resolve pericentromeric cohesion is under the control of the B-specific nondisjunction control region. Hence, a combination of nondisjunction and unequal spindle formation at first pollen mitosis results in the accumulation of Bs in the generative nucleus and therefore ensures their transmission at a higher than expected rate to the next generation.
引用
收藏
页码:4124 / 4134
页数:11
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