Magnetic Resonance Imaging-Based Neuromorphometry in Single Patients - A Proposal for its Usefulness

被引：1

作者：

Haenggi, Juergen ^{[1
]}

机构：

[1] Univ Zurich, Inst Psychol, Div Neuropsychol, CH-8050 Zurich, Switzerland

来源：

ZEITSCHRIFT FUR NEUROPSYCHOLOGIE | 2012年 / 23卷 / 02期

关键词：

Magnetic resonance imaging; neuromorphometry; grey matter; cortical thickness; fractional anisotropy; single patients; diagnosis; monitoring; semantic dementia; attention deficit hyperactivity disorder; disturbed social behaviour; synaesthesia; McLeod syndrome; VOXEL-BASED MORPHOMETRY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; CORTICAL THICKNESS; GRAY-MATTER; FRONTOTEMPORAL DEMENTIA; SEMANTIC DEMENTIA; CEREBRAL-CORTEX; SEX-DIFFERENCES; BRAIN ATROPHY; WHITE;

D O I：

10.1024/1016-264X/a000065

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The usefulness of MRI-based neuromorphometry for the investigation of single patients is described. A longitudinal cortical thickness analysis in a patient revealed lateral temporal lobe atrophy, suggesting rather semantic than frontotemporal dementia. A boy with the diagnosis of ADHD and control boys were compared and showed cortical thickness increases in the patient in the orbitofrontal cortex contradicting ADH D and suggesting disturbed social behaviour. The multiple synaesthetes E. S. was compared with control groups and showed hyperconnectivity between auditory and gustatory brain regions suggesting that interval-taste synaesthesia is rooted in anatomical alterations. McLeod syndrome patients were investigated and revealed severe atrophy of the caudate nucleus bilateral across time. Additionally, statistical recommendations for the comparison of MRI data of single patients are provided.

引用

页码：81 / 96

页数：16

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