Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection

被引：15

作者：

Russ, Brendan E. ^{[1
]}

Denton, Alice E. ^{[2
]}

Hatton, Lauren ^{[1
]}

Croom, Hayley ^{[1
]}

Olson, Matthew R. ^{[1
]}

Turner, Stephen J. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Univ Cambridge, Cambridge Res Inst, Dept Med, Cambridge, England

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

cytotoxic T cells; memory T cells; transcription factors; epigenetics; histone modifications; TRANSCRIPTION FACTOR; EFFECTOR FUNCTION; CUTTING EDGE; CHROMATIN SIGNATURES; EARLY ESTABLISHMENT; RECALL RESPONSES; CLONAL EXPANSION; DENDRITIC CELLS; RNA-POLYMERASE; CENTRAL MEMORY;

D O I：

10.3389/fimmu.2012.00371

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naive CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.

引用

页数：11

共 104 条

[61] Initial T cell frequency dictates memory CD8+ T cell lineage commitment [J].

Marzo, AL ;

Klonowski, KD ;

Le Bon, A ;

Borrow, P ;

Tough, DF ;

Lefrançois, L .

NATURE IMMUNOLOGY, 2005, 6 (08) :793-799

[62] Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue [J].

Masopust, David ;

Vezys, Vaiva ;

Marzo, Amanda L. ;

Lefrancois, Leo .

JOURNAL OF IMMUNOLOGY, 2014, 192 (03) :2413-2417

[63] 3 DISTINCT IL-2 SIGNALING PATHWAYS MEDIATED BY BCL-2, C-MYC, AND LCK COOPERATE IN HEMATOPOIETIC-CELL PROLIFERATION [J].

MIYAZAKI, T ;

LIU, ZJ ;

KAWAHARA, A ;

MINAMI, Y ;

YAMADA, K ;

TSUJIMOTO, Y ;

BARSOUMIAN, EL ;

PERLMUTTER, RM ;

TANIGUCHI, T .

CELL, 1995, 81 (02) :223-231

[64] Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection [J].

Moffat, Jessica M. ;

Gebhardt, Thomas ;

Doherty, Peter C. ;

Turner, Stephen J. ;

Mintern, Justine D. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (05) :1203-1210

[65] Role of T-bet in commitment of TH1 cells before IL-12-dependent selection [J].

Mullen, AC ;

High, FA ;

Hutchins, AS ;

Lee, HW ;

Villarino, AV ;

Livingston, DM ;

Kung, AL ;

Cereb, N ;

Yao, TP ;

Yang, SY ;

Reiner, SL .

SCIENCE, 2001, 292 (5523) :1907-1910

[66] RNA polymerase is poised for activation across the genome [J].

Muse, Ginger W. ;

Gilchrist, Daniel A. ;

Nechaev, Sergei ;

Shah, Ruchir ;

Parker, Joel S. ;

Grissom, Sherry F. ;

Zeitlinger, Julia ;

Adelman, Karen .

NATURE GENETICS, 2007, 39 (12) :1507-1511

[67] Cutting edge: Chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells [J].

Northrop, John K. ;

Wells, Andrew D. ;

Shen, Hao .

JOURNAL OF IMMUNOLOGY, 2008, 181 (02) :865-868

[68] Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells [J].

Northrop, John K. ;

Thomas, Rajan M. ;

Wells, Andrew D. ;

Shen, Hao .

JOURNAL OF IMMUNOLOGY, 2006, 177 (02) :1062-1069

[69]

Oehen S, 1998, J IMMUNOL, V161, P5338

[70] ChIP-seq: advantages and challenges of a maturing technology [J].

Park, Peter J. .

NATURE REVIEWS GENETICS, 2009, 10 (10) :669-680

← 2 3 4 5 6 7 8 9 10 11 →