Activated c-Abl tyrosine kinase in malignant solid tumors

被引:58
作者
Lin, J. [1 ]
Arlinghaus, R. [1 ]
机构
[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77054 USA
关键词
c-Abl; FUS1; NSCLC; lung cancer; imatinib; breast cancer;
D O I
10.1038/onc.2008.86
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mutant forms of the c-ABL gene are well known to be involved in hematopoietic malignancies such as chronic myeloid leukemia (CML). CML patients possess a fused BCR-ABL gene that activates the Abl tyrosine kinase domain within Bcr-Abl. In general fusion proteins that cause oligomerization of Abl lead to activation of its tyrosine kinase activity. In this review, we highlight recent discoveries indicating that the activated c-Abl tyrosine kinase, not as a fusion protein, plays an important role in malignant solid tumors of lung and breast.
引用
收藏
页码:4385 / 4391
页数:7
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