Characterization of the Human Papillomavirus (HPV) Integration Sites into Genital Cancers

被引：25

作者：

Annunziata, Clorinda ^{[1
]}

Buonaguro, Luigi ^{[1
]}

Buonaguro, Franco M. ^{[1
]}

Tornesello, Maria Lina ^{[1
]}

机构：

[1] Natl Canc Inst Fdn Pascale, Mol Biol & Viral Oncol & AIDS Reference Ctr, I-80131 Naples, Italy

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2012年 / 18卷 / 04期

关键词：

Human Papillomavirus; HPV; Integration sites; Penile cancer; Vulvar Cancer; PENILE CARCINOMAS; GENES; INFECTION; VULVAR; TRACT; MEN; DNA;

D O I：

10.1007/s12253-012-9507-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogenic HPVs have been found frequently integrated into human genome of invasive cancers and chromosomal localization has been extensively investigated in cervical carcinoma. Few studies have analyzed the HPV integration loci in other genital cancers. We have characterized the integration sites of HPV16 in invasive penile carcinoma by means of Alu-HPV-based PCR. Nucleotide sequence analysis of viral-human DNA junctions showed that HPV integration occurred in one case within the chromosome 8q21.3 region, in which the FAM92A1 gene is mapped, and in the second case inside the chromosome 16p13.3, within the intronic region of TRAP1 gene. These results confirm previous observations, summarized in a systematic review of the literature, on the HPV integration events in gene loci relevant to cancer pathogenesis.

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收藏

页码：803 / 808

页数：6

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