Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

被引：38
作者：
Kim, MJ
Yoo, YA
Kim, HJ
Kang, S
Kim, YG
Kim, JS
Yoo, YD [1 ]
机构：
[1] Korea Univ, Coll Med, Grad Sch Med, Seoul 136705, South Korea
[2] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136705, South Korea
[3] Yonsei Univ, Dept Internal Med, Coll Med, Seoul 135270, South Korea
[4] Korea Univ, Coll Med, Div Brain Korea 21 Program Biomed Sci, Seoul 136705, South Korea
[5] Korea Univ, Coll Med, Dept Internal Med, Seoul 136705, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 02期
关键词：
MRPL41; p21(WAF1/CIP1); serum starvation; p53; cell cycle; p27 (Kip1);
D O I：
10.1016/j.bbrc.2005.10.064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27(Kip1) in the absence of p53. This study found that MRPL41 mediates the p21(WAF1/CIP1)-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and P27(Kip1) levels under the growth inhibitory conditions. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：1179 / 1184
页数：6
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