Functional genomic analyses of the gut microbiota for CRC screening

被引：116

作者：

Konstantinov, Sergey R. ^{[1
]}

Kuipers, Ernst J. ^{[1
]}

Peppelenbosch, Maikel P. ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Erasmus MC, Dept Gastroenterol & Hepatol, NL-3015 CE Rotterdam, Netherlands

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2013年 / 10卷 / 12期

关键词：

LACTOBACILLUS-ACIDOPHILUS DEFICIENT; INFLAMMATORY-BOWEL-DISEASE; COLON-CANCER; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; LIPOTEICHOIC ACID; CROHNS-DISEASE; IMMUNE-SYSTEM; TUMOR-GROWTH; CELLS;

D O I：

10.1038/nrgastro.2013.178

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The evidence for a strong correlation between the gut microbiota and colorectal carcinogenesis is quickly gathering pace. This correlation raises important questions, such as whether analysis of the microbiota can be used for screening purposes, and whether targeted intervention can influence the risk of development and progression of neoplasia. The recovery of several pathobionts-such as members of the different bacterial phyla Proteobacteria, Bacteroidetes and Fusobacteria-from the tumour microenvironment of patients with colorectal cancer (CRC) now provides a link between specific microbial colonization and cancer. However, other intestinal bacteria belonging to another major intestinal phylum, Firmicutes, might be effective in the treatment of pathogenic inflammation related to CRC. Future approaches based on the analysis of the gut microbiota of patients with CRC combined with large human cohort studies might open up new possibilities for further prophylactic, screening and treatment strategies.

引用

页码：741 / 745

页数：5

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