PPARs and the complex journey to obesity

被引：1331

作者：

Evans, RM ^{[1
]}

Barish, GD

Wang, YX

机构：

[1] Salk Inst Biol Studies, Howard Hughes Med Inst, Gene Express Lab, La Jolla, CA 92037 USA

[2] Univ Calif San Francisco, Dept Med, Div Endocrinol & Metab, San Francisco, CA 94121 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nm1025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing' peroxisome proliferator-activated receptors (PPAR-alpha, PPAR-gamma and PPAR-delta) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.

引用

页码：355 / 361

页数：7

共 104 条

[91] A role for glucagon-like peptide-1 in the central regulation of feeding [J].

Turton, MD ;

OShea, D ;

Gunn, I ;

Beak, SA ;

Edwards, CMB ;

Meeran, K ;

Choi, SJ ;

Taylor, GM ;

Heath, MM ;

Lambert, PD ;

Wilding, JPH ;

Smith, DM ;

Ghatei, MA ;

Herbert, J ;

Bloom, SR .

NATURE, 1996, 379 (6560) :69-72

[92] HUMAN INSULIN-RECEPTOR AND ITS RELATIONSHIP TO THE TYROSINE KINASE FAMILY OF ONCOGENES [J].

ULLRICH, A ;

BELL, JR ;

CHEN, EY ;

HERRERA, R ;

PETRUZZELLI, LM ;

DULL, TJ ;

GRAY, A ;

COUSSENS, L ;

LIAO, YC ;

TSUBOKAWA, M ;

MASON, A ;

SEEBURG, PH ;

GRUNFELD, C ;

ROSEN, OM ;

RAMACHANDRAN, J .

NATURE, 1985, 313 (6005) :756-761

[93] Energy metabolism in uncoupling protein 3 gene knockout mice [J].

Vidal-Puig, AJ ;

Grujic, D ;

Zhang, CY ;

Hagen, T ;

Boss, O ;

Ido, Y ;

Szczepanik, A ;

Wade, J ;

Mootha, V ;

Cortright, R ;

Muoio, DM ;

Lowell, BB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (21) :16258-16266

[94] UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue [J].

VidalPuig, A ;

Solanes, G ;

Grujic, D ;

Flier, JS ;

Lowell, BB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (01) :79-82

[95] Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity [J].

Wang, YX ;

Lee, CH ;

Tiep, S ;

Yu, RT ;

Ham, JY ;

Kang, HJ ;

Evans, RM .

CELL, 2003, 113 (02) :159-170

[96] Disruption of IRS-2 causes type 2 diabetes in mice [J].

Withers, DJ ;

Gutierrez, JS ;

Towery, H ;

Burks, DJ ;

Ren, JM ;

Previs, S ;

Zhang, YT ;

Bernal, D ;

Pons, S ;

Shulman, GI ;

Bonner-Weir, S ;

White, MF .

NATURE, 1998, 391 (6670) :900-904

[97] Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 [J].

Wu, ZD ;

Puigserver, P ;

Andersson, U ;

Zhang, CY ;

Adelmant, G ;

Mootha, V ;

Troy, A ;

Cinti, S ;

Lowell, B ;

Scarpulla, RC ;

Spiegelman, BM .

CELL, 1999, 98 (01) :115-124

[98] Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity [J].

Wu, ZD ;

Rosen, ED ;

Brun, R ;

Hauser, S ;

Adelmant, G ;

Troy, AE ;

McKeon, C ;

Darlington, GJ ;

Spiegelman, BM .

MOLECULAR CELL, 1999, 3 (02) :151-158

[99] Cloning of adiponectin receptors that mediate antidiabetic metabolic effects [J].

Yamauchi, T ;

Kamon, J ;

Ito, Y ;

Tsuchida, A ;

Yokomizo, T ;

Kita, S ;

Sugiyama, T ;

Miyagishi, M ;

Hara, K ;

Tsunoda, M ;

Murakami, K ;

Ohteki, T ;

Uchida, S ;

Takekawa, S ;

Waki, H ;

Tsuno, NH ;

Shibata, Y ;

Terauchi, Y ;

Froguel, P ;

Tobe, K ;

Koyasu, S ;

Taira, K ;

Kitamura, T ;

Shimizu, T ;

Nagai, R ;

Kadowaki, T .

NATURE, 2003, 423 (6941) :762-769

[100] Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase [J].

Yamauchi, T ;

Kamon, J ;

Minokoshi, Y ;

Ito, Y ;

Waki, H ;

Uchida, S ;

Yamashita, S ;

Noda, M ;

Kita, S ;

Ueki, K ;

Eto, K ;

Akanuma, Y ;

Froguel, P ;

Foufelle, F ;

Ferre, P ;

Carling, D ;

Kimura, S ;

Nagai, R ;

Kahn, BB ;

Kadowaki, T .

NATURE MEDICINE, 2002, 8 (11) :1288-1295

← 2 3 4 5 6 7 8 9 10 11 →