Synthesis of isoquinolines by palladium-catalyzed cyclization, followed by a Heck reaction

被引：35

作者：

Huang, QH ^{[1
]}

Larock, RC ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(02)00579-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of 4-(1-alkenyl)-3-arylisoquinolines have been prepared by the Pd(II)-catalyzed cyclization of 2-(1-alkynyl)benzaldimines, followed by alkenylation (Heck reaction) in good to excellent yields. The introduction of an ortho-methoxy group on the benzaldimine promotes the Pd-catalyzed cyclization and stabilizes the resulting Pd(II) intermediate improving the yields of the desired isoquinoline products. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：3557 / 3560

页数：4

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