Role of hyperphosphatemia-mediated vascular calcification in cardiovascular outcomes and its management: a review

被引：7

作者：

Latif, Faisal ^{[1
,2
]}

Khalid, Muhammad Masood ^{[3
]}

Khan, Fahad ^{[1
]}

Omar, Zainab ^{[4
]}

Ali, Fazal Akbar ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Cardiovasc Sect, Oklahoma City, OK 73104 USA

[3] Dow Med Coll, Karachi, Pakistan

[4] King Edward Med Coll, Lahore, Pakistan

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2013年 / 14卷 / 06期

关键词：

coronary artery disease; hyperphosphatemia; vascular calcification; CHRONIC KIDNEY-DISEASE; CALCIUM-SENSING RECEPTOR; STAGE RENAL-DISEASE; CORONARY-ARTERY CALCIFICATION; FREE PHOSPHATE BINDER; ALL-CAUSE MORTALITY; EXTRACELLULAR CALCIUM; SERUM PHOSPHORUS; CARDIAC CALCIFICATION; AORTIC CALCIFICATION;

D O I：

10.2459/JCM.0b013e32835ec53d

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular diseases are the leading cause of death in patients with advanced renal disease. Although atherosclerosis is the major contributor, vascular calcification also plays an important role in progression of coronary as well as peripheral arterial disease in these patients. A large body of evidence suggests that hyperphosphatemia is the major contributor in progressive vascular calcification. We examine this large body of evidence with respect to the role of hyperphosphatemia in inducing vascular calcification and how, as a result, this possibly impacts an increase in adverse cardiovascular events. We also review various options as to how treating hyperphosphatemia might effect a decrease in cardiovascular morbidity and mortality.

引用

页码：410 / 415

页数：6

共 79 条

[1] The role of vitamin D in left ventricular hypertrophy and cardiac function [J].